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The evolution of gene expression levels in mammalian organs
Changes in gene expression are thought to underlie many of the phenotypic differences between species. However, large-scale analyses of gene expression evolution were until recently prevented byExpand
The evolution of lncRNA repertoires and expression patterns in tetrapods
We present a large-scale evolutionary study of lncRNA repertoires and expression patterns, in 11 tetrapod species. Expand
Origins and functional evolution of Y chromosomes across mammals
Y chromosomes underlie sex determination in mammals, but their repeat-rich nature has hampered sequencing and associated evolutionary studies. Here we trace Y evolution across 15 representativeExpand
Genome analysis of the platypus reveals unique signatures of evolution
This corrects the article DOI: 10.1038/nature06936
Bird-like sex chromosomes of platypus imply recent origin of mammal sex chromosomes.
In therian mammals (placentals and marsupials), sex is determined by an XX female: XY male system, in which a gene (SRY) on the Y affects male determination. There is no equivalent in other amniotes,Expand
Epigenetic conservation at gene regulatory elements revealed by non-methylated DNA profiling in seven vertebrates
Two-thirds of gene promoters in mammals are associated with regions of non-methylated DNA, called CpG islands (CGIs), which counteract the repressive effects of DNA methylation on chromatin. InExpand
Mechanisms and Evolutionary Patterns of Mammalian and Avian Dosage Compensation
A large-scale comparative gene expression study reveals the different ways in which the chromosome-wide gene dosage reductions resulting from sex chromosome differentiation events were compensatedExpand
The multiple sex chromosomes of platypus and echidna are not completely identical and several share homology with the avian Z
BackgroundSex-determining systems have evolved independently in vertebrates. Placental mammals and marsupials have an XY system, birds have a ZW system. Reptiles and amphibians have differentExpand
Platypus Pou5f1 reveals the first steps in the evolution of trophectoderm differentiation and pluripotency in mammals
SUMMARY Uterine nourishment of embryos by the placenta is a key feature of mammals. Although a variety of placenta types exist, they are all derived from the trophectoderm (TE) cell layer of theExpand
Genome analysis of the platypus reveals unique signatures of evolution
We present a draft genome sequence of the platypus, Ornithorhynchus anatinus. This monotreme exhibits a fascinating combination of reptilian and mammalian characters. For example, platypuses have aExpand