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The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry.
Susceptibility to autoimmune insulin-dependent (type 1) diabetes mellitus is determined by a combination of environmental and genetic factors, which include variation in MHC genes on chromosome 6p21Expand
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Cardiac troponins I and T are biological markers of left ventricular dysfunction in septic shock.
BACKGROUND Cardiac depression in severe sepsis and septic shock is characterized by left ventricular (LV) failure. To date, it is unclear whether clinically unrecognized myocardial cell injuryExpand
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Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism
HIF prolyl hydroxylases (PHD1–3) are oxygen sensors that regulate the stability of the hypoxia-inducible factors (HIFs) in an oxygen-dependent manner. Here, we show that loss of Phd1 lowers oxygenExpand
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Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes.
BACKGROUND Type 1 diabetes mellitus is a T-cell-mediated autoimmune disease that leads to a major loss of insulin-secreting beta cells. The further decline of beta-cell function after clinical onsetExpand
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Plasma procalcitonin and C-reactive protein in acute septic shock: Clinical and biological correlates
Objective To determine the relationship between plasma procalcitonin (PCT) levels, C-reactive protein (CRP), white blood cell count (WBC), ionized calcium (Ca2+), and patient outcome; and to compareExpand
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The epidemiology of Type 1 diabetes mellitus is not the same in young adults as in children
Aims/hypothesisThis prospective study examined the epidemiology of Type 1 diabetes in young adults in Europe.MethodsWe ascertained incident cases of Type 1 diabetes in the 15 to 29 years (bothExpand
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Four-year metabolic outcome of a randomised controlled CD3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual beta cell mass
Aims/hypothesisThe aim of the study was to examine the 48 month outcome of treating recent-onset type 1 diabetic patients for 6 days with humanised CD3-antibody, ChAglyCD3.MethodsEighty patients,Expand
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Screening for Insulitis in Adult Autoantibody-Positive Organ Donors
Antibodies against islet cell antigens are used as predictive markers of type 1 diabetes, but it is unknown whether they reflect an ongoing autoimmune process in islet tissue. We investigated whetherExpand
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Beta‐cell, thyroid, gastric, adrenal and coeliac autoimmunity and HLA‐DQ types in type 1 diabetes
The autoimmune attack in type 1 diabetes is not only targeted to β cells. We assessed the prevalence of thyroid peroxidase (aTPO), parietal cell (PCA), antiadrenal (AAA) and endomysial antibodiesExpand
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Cellular Islet Autoimmunity Associates with Clinical Outcome of Islet Cell Transplantation
Background Islet cell transplantation can cure type 1 diabetes (T1D), but only a minority of recipients remains insulin–independent in the following years. We tested the hypothesis that allograftExpand
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