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Comorbidity of mental disorders with alcohol and other drug abuse. Results from the Epidemiologic Catchment Area (ECA) Study.
Comorbidity of addictive and severe mental disorders was highest in the prison population, most notably with antisocial personality, schizophrenia, and bipolar disorders. Expand
Seasonal affective disorder. A description of the syndrome and preliminary findings with light therapy.
Preliminary studies in 11 patients suggest that extending the photoperiod with bright artificial light has an antidepressant effect and sleep recordings in nine depressed patients confirmed the presence of hypersomnia and showed increased sleep latency and reduced slow-wave (delta) sleep. Expand
Manic-Depressive Illness
Psychodynamic features of families with multigenerational bipolar manic-depressive illness are described. Repetitive maladaptive patterns, including avoidance of affect, unrealistic standards ofExpand
The de facto US mental and addictive disorders service system. Epidemiologic catchment area prospective 1-year prevalence rates of disorders and services.
Potential 1-year prevalence and service use rates of mental and addictive disorders in the US population and applications to US health care system reform options are considered in the context of other variables that will determine national health policy. Expand
Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines
The increased exploratory activity with benzodiazepines does not appear to be a non-specific increase in general motor activity, as locomotion in clonazepam and chlordiazepoxide treated mice placed in a bare, undifferentiated cage was not significantly different from vehicle treated mice. Expand
Manic-Depressive Illness. Bipolar Disorders and Recurrent Depression. Oxford (Oxford University Press) 2007.
The Bipolar-Unipolar Distinction and the Development of the Manic-Depressive Spectrum are conceptualized and the clinical description and assessment, and the Fundamentals of Treatment are outlined. Expand
Aggression in humans correlates with cerebrospinal fluid amine metabolites
Cerebrospinal fluid of the major central metabolites of serotonin, norepinephrine, and dopamine--5HIAA, 3-methoxy-4-hydroxy=phenylglycol (MHPG), and homovanillic acid (HVA), respectively--were studied in a group of 26 age-similar military men with no history of major psychiatric illness, but with various personality disorders and difficulties adjusting to military life. Expand
“Cade's Disease” and Beyond: Misdiagnosis, Antidepressant Use, and a Proposed Definition for Bipolar Spectrum Disorder
A critical review of studies concerning the nosology of bipolar disorder and the effects of antidepressant agents leads to the conclusion that there should be less emphasis on using antidepressants to treat sons with this illness. Expand
Aggression, suicide, and serotonin: relationships to CSF amine metabolites.
The life history of aggression and history of suicidal behavior in 12 subjects with borderline personality disorders without major affective disorder were examined, and Histories of aggressive behaviors and of suicide attempts were significantly associated with each other. Expand
Suicide risk in bipolar disorder during treatment with lithium and divalproex.
Among patients treated for bipolar disorder, risk of suicide attempt and suicide death is lower during treatment with lithium than duringreatment with divalproex, according to a retrospective cohort study conducted at 2 large integrated health plans in California and Washington. Expand