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Human cytomegalovirus sequences expressed in latently infected individuals promote a latent infection in vitro.
This is the first functional demonstration of a virus-coded sequence required for HCMV latency, and UL138 RNA was expressed in CD34(+) cells and monocytes from HCMv-seropositive, healthy individuals, suggesting it might be a target for antivirals against latent virus.
Human cytomegalovirus gene expression during infection of primary hematopoietic progenitor cells: A model for latency
- F. Goodrum, C. Jordan, K. High, T. Shenk
- Biology, MedicineProceedings of the National Academy of Sciences…
- 27 November 2002
An in vitro system in which to study HCMV infection and latency in CD34+ cells cultured with irradiated stromal cells is developed and altered gene expression in hematopoietic progenitors may be indicative of the nature and outcome of H CMV infection.
Characterization of a Novel Golgi Apparatus-Localized Latency Determinant Encoded by Human Cytomegalovirus
- Alex S Petrucelli, Michael A Rak, L. Grainger, F. Goodrum
- Biology, MedicineJournal of Virology
- 18 March 2009
ABSTRACT Human cytomegalovirus (HCMV) exists indefinitely in infected individuals by a yet poorly characterized latent infection in hematopoietic cells. We previously demonstrated a requirement for…
p53 Status Does Not Determine Outcome of E1B 55-Kilodalton Mutant Adenovirus Lytic Infection
The capacity of the E1B 55-kDa mutant virus to replicate independently of the cell cycle does not correlate with the status of p53 but is determined by yet unidentified mechanisms, which is speculated to be linked to late gene expression and cell cycle-independent replication.
Differential outcomes of human cytomegalovirus infection in primitive hematopoietic cell subpopulations.
It is demonstrated that the outcome of HCMV infection in the hematopoietic compartment is dependent on the nature of the cell subpopulations infected and that CD34+/CD38- cells support an H CMV infection with the hallmarks of latency.
Adenovirus early region 4 34-kilodalton protein directs the nuclear localization of the early region 1B 55-kilodalton protein in primate cells
Results suggest that a primate cell-specific factor mediates the functional interaction of the E1B and E4 proteins of adenovirus.
The early region 1B 55-kilodalton oncoprotein of adenovirus relieves growth restrictions imposed on viral replication by the cell cycle
A novel property of the large tumor antigen of adenovirus in relieving growth restrictions imposed on viral replication by the cell cycle is defined, which means the inability of the E1B mutant virus to replicate was not mediated by the status of p53.
A Novel Human Cytomegalovirus Locus Modulates Cell Type-Specific Outcomes of Infection
- M. Umashankar, Alex S Petrucelli, +10 authors F. Goodrum
- Biology, MedicinePLoS pathogens
- 1 December 2011
In vitro findings to analyze viral replication and dissemination in a NOD-scid IL2Rγc null-humanized mouse model were extended and the UL133-UL138 NULL virus exhibited an increased capacity for replication and/or dissemination following stem cell mobilization relative to the wild-type virus, suggesting an important role in viral persistence and spread in the host.
Human cytomegalovirus persistence
This review focuses on recent advances in the biology of HCMV persistence, particularly with respect to the latent mode of persistence, as herpesviruses are met with similar challenges in achieving latency and often employ conserved strategies to persist.
Tissue reservoirs of antiviral T cell immunity in persistent human CMV infection
- C. Gordon, M. Miron, +8 authors D. Farber
- Biology, MedicineThe Journal of experimental medicine
- 27 January 2017
T cell differentiation was enhanced in sites of viral persistence with age, and tissue T cell reservoirs for CMV control shaped by both viral and tissue-intrinsic factors, with global effects on homeostasis of tissue T cells over the lifespan.