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Diastereomeric quinolinone alkaloids from the marine-derived fungus Penicillium janczewskii.
TLDR
Cytotoxicity testing on eight tumor cell lines revealed a moderate specificity of 2 on SKOV-3 cells, and two new diastereomeric quinolinones were identified.
Cervimycin A-D: a polyketide glycoside complex from a cave bacterium can defeat vancomycin resistance.
TLDR
Cervimycins A-D are novel polyketide glycosides with significant activity against multi-drug-resistant staphylococci and vancomycin-resistant enterococci, isolated from an ancient cave.
Biosynthesis of cervimycin C, an aromatic polyketide antibiotic bearing an unusual dimethylmalonyl moiety.
TLDR
The biosynthetic origin of cervimycin was studied by molecular studies and feeding experiments, which reveal that the dimethylmalonate unit is not derived from malonate, but from valine.
Solution structure of a five-adenine bulge loop within a DNA duplex.
TLDR
The three-dimensional solution structure of a DNA molecule paired with 5'-d(CGTAGCCGATGC)-3' containing a five-adenine bulge loop (dA(5)-bulge) between two double helical stems was determined by 2D (1)H and (31)P NMR, infrared, and Raman spectroscopy.
Interaction of anthracycline antibiotics with biopolymers. VIII. Binding parameters of aclacinomycin A to DNA.
TLDR
The binding of aclacinomycin A to DNA was investigated spectrophotometrically under equilibrium conditions and the self-association behaviour was identified as dimerization, which was compared with those of adriamycin, daunomycin, and iremycin to draw some conclusions regarding the structural specialities of a clacinomcin A.
Hexacyclinol, a new antiproliferative metabolite of Panus rudis HKI 0254.
TLDR
Hexacyclinol was discovered as a novel, unusual, oligocyclic metabolite in cultures of the fungal strain Panus rudis HKI 0254, isolated from basidiospores of this fungus found on dead betula woods collected near Irkutsk.
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