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Borrelia burgdorferi sigma54 is required for mammalian infection and vector transmission but not for tick colonization.
Previous studies have shown that a sigma54-sigma(S) cascade regulates the expression of a few key lipoproteins in Borrelia burgdorferi, the agent of Lyme disease. Here, we demonstrate that theseExpand
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Insights into the complex regulation of rpoS in Borrelia burgdorferi
Co‐ordinated regulation of gene expression is required for the transmission and survival of Borrelia burgdorferi in different hosts. The sigma factor RpoS (σS), as regulated by RpoN (σ54), has beenExpand
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Lack of a role for iron in the Lyme disease pathogen.
A fundamental tenet of microbial pathogenesis is that bacterial pathogens must overcome host iron limitation to establish a successful infection. Surprisingly, the Lyme disease pathogen BorreliaExpand
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Borrelia oxidative stress response regulator, BosR: A distinctive Zn-dependent transcriptional activator
The ability of a pathogen to cause infection depends on successful colonization of the host, which, in turn, requires adaptation to various challenges presented by that host. For example, host immuneExpand
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Characterization of a manganese-dependent regulatory protein, TroR, from Treponema pallidum.
Genome sequence analysis of Treponema pallidum, the causative agent of syphilis, suggests that this bacterium has a limited iron requirement with few, if any, proteins that require iron. Instead, T.Expand
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The critical role of the linear plasmid lp36 in the infectious cycle of Borrelia burgdorferi
Borrelia burgdorferi, the aetiological agent of Lyme disease, follows a life cycle that involves passage between the tick vector and the mammalian host. To investigate the role of the 36 kb linearExpand
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Borrelia burgdorferi membranes are the primary targets of reactive oxygen species
Spirochetes living in an oxygen‐rich environment or when challenged by host immune cells are exposed to reactive oxygen species (ROS). These species can harm/destroy cysteinyl residues, iron‐sulphurExpand
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Borrelia burgdorferi bb0728 encodes a coenzyme A disulphide reductase whose function suggests a role in intracellular redox and the oxidative stress response
The cellular responses of Borrelia burgdorferiTo reactive oxygen species (ROS) encountered during the different stages of its infective cycle are poorly understood. Few enzymes responsible forExpand
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Burkholderia pseudomallei Type III Secretion System Mutants Exhibit Delayed Vacuolar Escape Phenotypes in RAW 264.7 Murine Macrophages
ABSTRACT Burkholderia pseudomallei is a facultative intracellular pathogen capable of surviving and replicating within eukaryotic cells. Recent studies have shown that B. pseudomallei Bsa type IIIExpand
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Purine Salvage Pathways among Borrelia Species
ABSTRACT Genome sequencing projects on two relapsing fever spirochetes, Borrelia hermsii and Borrelia turicatae, revealed differences in genes involved in purine metabolism and salvage compared toExpand
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