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The ch-TOG/XMAP215 protein is essential for spindle pole organization in human somatic cells.
TLDR
In human somatic cells, ch-TOG appears to play a major role in organizing spindle poles, and a more minor role in stabilizing spindle microtubules that is, at least in part, mediated via an interaction with TACC3. Expand
Msps/XMAP215 interacts with the centrosomal protein D-TACC to regulate microtubule behaviour
TLDR
It is shown here that Msps (mini-spindles protein) interacts with the centrosomal protein D-TACC, and that this interaction strongly influences microtubule behaviour in Drosophila embryos. Expand
INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse
TLDR
It is reported that mice deficient for the lipid 5-phosphatase Inpp5e develop a multiorgan disorder associated with structural defects of the primary cilium, and the results show that INPP5E plays an essential role in the primarycilium by controlling ciliary growth factor and PI3K signaling and stability. Expand
The mago nashi gene is required for the polarisation of the oocyte and the formation of perpendicular axes in Drosophila
TLDR
It is shown that mago nashi mutant oocytes develop a symmetric microtubule cytoskeleton that leads to the transient localisation of bicoid mRNA to both poles, resulting in a novel phenotype in which the anterior of the egg is ventralised and the posterior dorsalised, demonstrating that the migration of the oocyte nucleus determines the relative orientation of the two principal axes of Drosophila. Expand
WDR62 is associated with the spindle pole and is mutated in human microcephaly
TLDR
In human and mouse embryonic brain, it was found that WDR62 expression was restricted to neural precursors undergoing mitosis, lending support to the hypothesis that the exquisite control of the cleavage furrow orientation in mammalian neural precursor cell mitosis is critical both in causing MCPH when perturbed and, when modulated, generating the evolutionarily enlarged human brain. Expand
Aurora-A: the maker and breaker of spindle poles
TLDR
Recent advances in determining the early mitotic role of Aurora-A are discussed, with a strong emphasis on its function at the mitotic spindle poles. Expand
A Primary Microcephaly Protein Complex forms a ring around parental centrioles
TLDR
Using super-resolution microscopy, this work suggests that the CEP152-CEP63 ring-like structure ensures normal neurodevelopment and that its impairment particularly affects human cerebral cortex growth. Expand
D‐TACC: a novel centrosomal protein required for normal spindle function in the early Drosophila embryo
TLDR
Drosophila TACC is identified as a novel protein that is concentrated at centrosomes and interacts with microtubules, and the C‐terminal region is related to the mammalian transforming, acidic, coiled‐coil‐containing (TACC) family of proteins. Expand
The essential role of centrosomal NDE1 in human cerebral cortex neurogenesis.
TLDR
Examining human and mouse embryonic brains, it is determined that NDE1 is highly expressed in neuroepithelial cells of the developing cerebral cortex, particularly at the centrosome, and it is shown that NDI accumulates on the mitotic spindle of apical neural precursors in early neurogenesis. Expand
The TACC domain identifies a family of centrosomal proteins that can interact with microtubules.
TLDR
The TACC domain identifies a family of centrosomal proteins that can interact with microtubules, which may explain the link between the TACC genes and cancer. Expand
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