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Blood monocytes consist of two principal subsets with distinct migratory properties.
TLDR
Using a murine adoptive transfer system to probe monocyte homing and differentiation in vivo, two functional subsets among murine blood monocytes are identified: a short-lived CX(3)CR1(lo)CCR2(+)Gr1(+) subset that is actively recruited to inflamed tissues and a CX (3) CR1(hi)CCS1-dependent recruitment to noninflamed tissues. Expand
Development of Monocytes, Macrophages, and Dendritic Cells
TLDR
The current understanding of myeloid lineage development is reviewed and the developmental pathways and cues that drive differentiation are described, which are central to the development of immunologic memory and tolerance in mice. Expand
Human CD14dim Monocytes Patrol and Sense Nucleic Acids and Viruses via TLR7 and TLR8 Receptors
TLDR
CD14dim monocytes were weak phagocytes and did not produce ROS or cytokines in response to cell-surface Toll-like receptors, but selectively produced TNF-α, IL-1β, and CCL3 inresponse to viruses and immune complexes containing nucleic acids, via a proinflammatory TLR7-TLR 8-MyD88-MEK pathway. Expand
Blood monocytes: development, heterogeneity, and relationship with dendritic cells.
TLDR
Functional characterization of monocytes is in progress in humans and rodents and will provide a better understanding of the pathophysiology of inflammation. Expand
A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
TLDR
It is found that the transcription factor Myb was required for development of HSCs and all CD11bhigh monocytes and macrophages, but was dispensable for yolk sac (YS)macrophages and for the development of YS-derived F4/80bright macrophage populations in several tissues. Expand
Monitoring of Blood Vessels and Tissues by a Population of Monocytes with Patrolling Behavior
TLDR
It is shown, by direct examination of blood monocyte functions in vivo, that a subset of monocytes patrols healthy tissues through long-range crawling on the resting endothelium, which initiated an early immune response and differentiated into macrophages. Expand
A Clonogenic Bone Marrow Progenitor Specific for Macrophages and Dendritic Cells
TLDR
The isolation and clonal analysis of a mouse bone marrow progenitor that is specific for monocytes, several macrophage subsets, and resident spleen DCs in vivo is described, providing a cellular and molecular basis for the concept of the mononuclear phagocyte system. Expand
Activation-Induced Cytidine Deaminase (AID) Deficiency Causes the Autosomal Recessive Form of the Hyper-IgM Syndrome (HIGM2)
TLDR
The phenotype observed in HIGM2 patients (and in AID-/- mice) demonstrates the absolute requirement for AID in several crucial steps of B cell terminal differentiation necessary for efficient antibody responses. Expand
TLR3 Deficiency in Patients with Herpes Simplex Encephalitis
TLDR
Human TLR3 appears to be redundant in host defense to most microbes but is vital for natural immunity to HSV-1 in the CNS, which suggests that neurotropic viruses have contributed to the evolutionary maintenance ofTLR3. Expand
Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors
TLDR
It is shown in mice that the vast majority of adult tissue-resident macrophages originate from a Tie2+ (also known as Tek) cellular pathway generating Csf1r+ erythro-myeloid progenitors (EMPs) distinct from HSCs. Expand
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