Inflammatory mediators in human acute pancreatitis: clinical and pathophysiological implications
The results suggest that local mediator release, with a probable IL-1β-IL-1RA imbalance in severe cases, is followed by the systemic appearance of pro- and anti-inflammatory mediators.
Tumor of the ampulla of Vater: experience with local or radical resection in 171 consecutively treated patients.
- H. Beger, F. Treitschke, F. Gansauge, N. Harada, N. Hiki, T. Mattfeldt
- MedicineArchives of Surgery
- 1 May 1999
In patients with villous adenoma of the ampulla, ampullectomy was an adequate surgical treatment and the prognosis after oncological resection of cancer of the Ampulla is determined by the absence of lymph node metastasis, the presence of infiltration into the pancreatic head tissue and the application of an R0 resection.
The potential role of procalcitonin and interleukin 8 in the prediction of infected necrosis in acute pancreatitis
Procalcitonin (PCT), a 116 amino acid propeptide of calcitonin, and interleukin 8 (IL-8), a strong neutrophil activating cytokine, are markers of severe inflammation and sepsis and are found in high concentrations in infected necrosis and associated systemic complications in patients with acute pancreatitis.
Treatment of Pancreatic Cancer: Challenge of the Facts
After oncological resection of pancreatic cancer each patient should be offered adjuvant treatment, and the assessment of clinical benefit from surgical or medical cancer treatment should therefore be based on several end points, not only on actuarial survival.
Biglycan is overexpressed in pancreatic cancer and induces G1-arrest in pancreatic cancer cell lines.
The ECM protein PG-I inhibits growth by arresting pancreatic cancer cells in G1 and may be part of a host defense mechanism aimed at slowing down pancreatic tumor progression.
Regulation of cell growth and cyclin D1 expression by the constitutively active FRAP-p70s6K pathway in human pancreatic cancer cells.
- M. Grewe, F. Gansauge, R. Schmid, G. Adler, T. Seufferlein
- Biology, ChemistryCancer Research
- 1 August 1999
Inhibitors of the constitutively active FRAP-p70s6K pathway may provide a novel therapeutic approach for pancreatic cancer.
The role of polymorphonuclear leukocytes and oxygen‐derived free radicals in experimental acute pancreatitis: mediators of local destruction and activators of inflammation
The clinical value of procalcitonin in the prediction of infected necrois in acute pancreatitis
- B. Rau, G. Steinbach, K. Baumgart, F. Gansauge, A. Grünert, H. Beger
- MedicineIntensive Care Medicine
- 1 February 2000
Monitoring of serum PCT could serve as a noninvasive and accurate method to predict IN in AP as well as to select patients with persisting septic complications after surgical debridement.
Overexpression of glucose transporter 1 and increased FDG uptake in pancreatic carcinoma.
The concomitant enhancement of glucose utilization and selective overexpression of GlUT-1 mRNA in pancreatic cancer but not in MFP suggested constitutive activation of Glut-1 gene or decreased degradation ofglucose metabolism in human pancreaticcancer.
Cystic tumours of the pancreas: diagnostic accuracy, pathologic observations and surgical consequences
Surgical resection is recommended in all cystic tumours, even in serous Cystadenoma, because symptoms may develop and malignant transformation to serous cystadenocarcinoma is possible.