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Activation of TMSCN by N-heterocyclic carbenes for facile cyanosilylation of carbonyl compounds.
N-Heterocyclic carbenes were found to be highly effective organocatalysts in activating TMSCN for facile cyanosilylation of carbonyl compounds. Cyano transfer from TMSCN to aldehydes and ketonesExpand
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Hydrogenation of Esters to Alcohols with a Well‐Defined Iron Complex.
The process involves a base-free reduction in the presence of the novel iron complex AIPC without any additives.
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Two epidemiologically related cases ofRahnella aquatilis bacteremia
Rahnella aquatilis was isolated from the blood cultures of two patients who were in different units of the same hospital. Both isolates were susceptible to aminoglycosides, fluoroquinolones,Expand
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Synthesis of Functionalized 1,3-Butadienes via Pd-Catalyzed Cross-Couplings of Substituted Allenic Esters in Water at Room Temperature.
An environmentally responsible, mild method for the synthesis of functionalized 1,3-butadienes is presented. It utilizes allenic esters of varying substitution patterns, as well as a wide range ofExpand
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Organometallic methods for the synthesis and functionalization of azaindoles.
Azaindoles (also called pyrrolopyridines) constitute essential subunits in many pharmaceutically important compounds. The synthesis of azaindoles has been a great synthetic challenge for chemists.Expand
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N-heterocyclic carbene catalyzed trifluoromethylation of carbonyl compounds.
[reaction: see text]. A novel N-heterocyclic carbene (NHC) catalyzed trifluoromethylation reaction of carbonyl compounds was discovered. Both enolizable and nonenolizable aldehydes and alpha-ketoExpand
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Hydrierung von Estern zu Alkoholen mit einem definierten Eisenkomplex
Wir prasentieren die erste basenfreie Fe-katalysierte Esterreduktion unter Verwendung von molekularem Wasserstoff. Eine Vielzahl von Carbonsaureestern und Lactonen konnte ohne den Einsatz vonExpand
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Evolution of Solvents in Organic Chemistry
An overview is presented on the unfortunate use of organic solvents as the traditional medium in which organic synthesis has been, and continues to be, practiced. An argument is made, from theExpand
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HandaPhos: A General Ligand Enabling Sustainable ppm Levels of Palladium-Catalyzed Cross-Couplings in Water at Room Temperature.
The new monophosphine ligand HandaPhos has been identified such that when complexed in a 1:1 ratio with Pd(OAc)2, enables Pd-catalyzed cross-couplings to be run using ≤1000 ppm of this pre-catalyst.Expand
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Sustainability Challenges in Peptide Synthesis and Purification: From R&D to Production.
In recent years, there has been a growing interest in therapeutic peptides within the pharmaceutical industry with more than 50 peptide drugs on the market, approximately 170 in clinical trials, andExpand
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