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Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation
TLDR
It is confirmed that in the adult rat brain, neuronal progenitor cells divide at the border between the hilus and the granule cell layer (GCL) and in adult rats, the progeny of these cells migrate into the GCL and express the neuronal markers NeuN and calbindin-D28k.
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Running enhances neurogenesis, learning, and long-term potentiation in mice.
TLDR
The results indicate that physical activity can regulate hippocampal neurogenesis, synaptic plasticity, and learning.
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A Functional Role for Adult Hippocampal Neurogenesis in Spatial Pattern Separation
TLDR
Using adult mice in which hippocampal neurogenesis was ablated, this work found specific impairments in spatial discrimination with two behavioral assays: a spatial navigation radial arm maze task and a spatial, but non-navigable, task in the mouse touch screen.
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Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male sprague–dawley rats in vivo
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Nucleus basalis and thalamic control of neocortical activity in the freely moving rat
TLDR
It is suggested that the NB system may serve as a structural basis for the concept of the generalized ascending activation of Moruzzi and Magoun (1949) by directly activating the neocortex and by suppressing the rhythm generation in the RT-thalamocortical circuitry.
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NGF improves spatial memory in aged rodents as a function of age
TLDR
NGF-infused rats showed improved retention of previously acquired place navigation performance and improved spatial acuity over the former platform site when the invisible platform was removed and NGF infusion also had a significant effect in the much more severely impaired 30-month-old rats.
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Petit mal epilepsy and parkinsonian tremor: Hypothesis of a common pacemaker
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Spinal cord neuroblasts proliferate in response to basic fibroblast growth factor
  • J. Ray, F. Gage
  • Biology
    The Journal of neuroscience : the official…
  • 1 June 1994
TLDR
It is reported that basic fibroblast growth factor at high concentrations (bFGF) is a mitogen for embryonic spinal cord cells that have already committed to a neuronal pathway and are expressing neuronal phenotypes (neuroblasts) and that bFGF has mitogenic effects preferably on neuroblasts.
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Regional changes in brain glucose metabolism reflect cognitive impairments in aged rats
TLDR
The results show that the individual rats within an aged rat population develop cognitive impairments to a variable degree and that the aged rats with the most pronounced learning impairments are the ones exhibiting the most severe functional decrements, in terms of glucose utilization, in the septohippocampal system and the prefrontal cortex.
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Somatic gene transfer of nerve growth factor promotes the survival of axotomized septal neurons and the regeneration of their axons in adult rats
TLDR
The data reveal that NGF-producing grafts sustain a significantly higher proportion of NGF receptor-immunoreactive septal neurons following axotomy and promote axon regeneration and cholinergic reinnervation of dentate granular neurons by these lesioned neurons.
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