• Publications
  • Influence
Inhibition of the c-Abl–TAp63 pathway protects mouse oocytes from chemotherapy-induced death
Germ cells are sensitive to genotoxins, and ovarian failure and infertility are major side effects of chemotherapy in young patients with cancer. Here we describe the c-Abl–TAp63 pathway activated byExpand
  • 247
  • 13
In vitro development of growing oocytes from fetal mouse oocytes: stage-specific regulation by stem cell factor and granulosa cells.
The development of follicles in the mammalian ovary involves a bidirectional communication system between the follicular cells and oocyte that is now beginning to be characterized. Little is knownExpand
  • 115
  • 6
Kit regulatory elements required for expression in developing hematopoietic and germ cell lineages.
The Kit (White) gene encodes the transmembrane receptor of stem cell factor/Kit ligand (KL) and is essential for the normal development/maintenance of pluripotent primordial germ cells (PGCs),Expand
  • 75
  • 5
Poly(ADP-ribosyl)ation Acts in the DNA Demethylation of Mouse Primordial Germ Cells Also with DNA Damage-Independent Roles
Poly(ADP-ribosyl)ation regulates chromatin structure and transcription driving epigenetic events. In particular, Parp1 is able to directly influence DNA methylation patterns controlling transcriptionExpand
  • 58
  • 5
Akt/PTEN signaling mediates estrogen-dependent proliferation of primordial germ cells in vitro.
Testicular tumors in humans are reported to be significantly increasing in incidence. Embryo exposure to environmental estrogens has been proposed as one of the possible underlying causes. In mice,Expand
  • 95
  • 4
Analysis of programmed cell death in mouse fetal oocytes.
We report a short-term culture system that allows to define novel characteristic of programmed cell death (PCD) in fetal oocytes and to underscore new aspects of this process. Mouse fetal oocytesExpand
  • 63
  • 4
Establishment of oocyte population in the fetal ovary: primordial germ cell proliferation and oocyte programmed cell death.
Strict control of cell proliferation and cell loss is essential for the coordinated functions of different cell populations in complex multicellular organisms. Oogenesis is characterized by a firstExpand
  • 89
  • 3
Derivation in culture of primordial germ cells from cells of the mouse epiblast: phenotypic induction and growth control by Bmp4 signalling
Primordial germ cells (PGCs) are the embryonic precursors of the gametes of the adult. PGCs derive from cells of the most proximal part of the cup-shaped epiblast corresponding to the presumptiveExpand
  • 84
  • 2
Experimental approaches to the study of primordial germ cell lineage and proliferation.
New information regarding primordial germ cell (PGC's) segregation and proliferation over the last decade is reviewed. Advances have been obtained in the mouse but current knowledge of human PGC'sExpand
  • 67
  • 2
LH prevents cisplatin-induced apoptosis in oocytes and preserves female fertility in mouse
Premature ovarian failure and female infertility are frequent side effects of anticancer therapies, owing to the extreme sensitivity of the ovarian reserve oocytes to the damaging effects ofExpand
  • 36
  • 1