F. Fusi

Publications114
h-index23
Citations1,515
Highly Influential Citations37
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(+/−)‐Naringenin as large conductance Ca2+‐activated K+ (BKCa) channel opener in vascular smooth muscle cells
The aim of this study was to investigate, in vascular smooth muscle cells, the mechanical and electrophysiological effects of (+/−)‐naringenin.
Effects of quercetin and rutin on vascular preparations
TLDR
The mechanical and electrophysiological properties of quercetin and its rutoside, rutin, are investigated in an attempt to clarify how Ca2+ channel activation might be related to the myorelaxing activity. Expand
Quercetin as a novel activator of L‐type Ca2+ channels in rat tail artery smooth muscle cells
TLDR
Results prove quercetin to be a naturally‐occurring L‐type Ca2+ channel activator and slows both the activation and the deactivation kinetics of the ICa(L). Expand
Rectal temperature and prostaglandin E2 increase in cerebrospinal fluid of conscious rabbits after intracerebroventricular injection of hemoglobin
TLDR
Findings indicate that, once Hb is released into the subarachnoid space during SAH, it enhances CSF PGE2 content and elicits hyperthermia, thus offering an explanation for the fever that is an aggravating condition in most SAH patients. Expand
Cytochrome P450-dependent N-dealkylation of L-deprenyl in C57BL mouse liver microsomes: effects of in vivo pretreatment with ethanol, phenobarbital, beta-naphthoflavone and L-deprenyl.
TLDR
By reducing CYP content, L-deprenyl treatment may impair the metabolic disposition of other drugs given in combination regimens, and it is suggested that the N-dealkylation pathways of deprenyl are inhibited by 4-methylpyrazole and disulfiram, two CYP2E1 inhibitors. Expand
Characterization of voltage-gated calcium currents in freshly isolated smooth muscle cells from rat tail main artery.
TLDR
It is shown that smooth muscle cells freshly isolated from rat tail main artery may be divided into two populations, one expressing both L- and T- type and the other only L-type Ca2+ channels, and cinnarizine potently inhibited T-type currents at low concentrations but also blocked L- type Ca2+. Expand
The surge of flavonoids as novel, fine regulators of cardiovascular Cav channels
TLDR
Examining numerous studies aimed at analysing flavonoids intrinsic mechanism of action at cardiovascular Cav channels finds that flavonoid‐membrane interaction, bioavailability, and antioxidant activity are taken into account and discussed. Expand
The flavonoid scaffold as a template for the design of modulators of the vascular Cav1.2 channels
TLDR
The proposition that the flavonoid structure confers the ability to modulate Cav1.2 channels is tested and it is shown that it does. Expand
Effects of 2,5-di-t-butyl-1,4-benzohydroquinone (BHQ) on rat aorta smooth muscle.
TLDR
The results indicate that the myotonic effect of BHQ on rat aortic rings depends on activation of Ca2+ influx via a Ni2+-sensitive pathway, whereas its myolytic activity is due either to antagonism ofCa2+ entry via L-type Ca2+. Expand
Effects of some sterically hindered phenols on whole‐cell Ca2+ current of guinea‐pig gastric fundus smooth muscle cells
TLDR
The inhibition of ICa(L) by BHA and DTBHA is qualitatively similar to that of a Ca2+ channel blocker and is characterized by the stabilizing effect of the inactivated state of the channel. Expand
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