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Androgen receptor defects : Historical, clinical, and molecular perspectives
I. Introduction IN 1953 lohn Morris, an obstetrician at Yale University, reported a series of 82 individuals (80 cases collated from the literature and two cases of his own) who had a femaleExpand
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The Androgen Axis in Recurrent Prostate Cancer
Purpose. Prostate cancer that recurs during androgen deprivation therapy is referred to as androgen-independent. High levels of expression of androgen receptor and androgen receptor-regulated genesExpand
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Androgen receptor stabilization in recurrent prostate cancer is associated with hypersensitivity to low androgen.
The androgen receptor (AR) is highly expressed in androgen-dependent and recurrent prostate cancer (CaP) suggesting it has a role in the growth and progression of CaP. Previously proposed mechanismsExpand
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A mechanism for androgen receptor-mediated prostate cancer recurrence after androgen deprivation therapy.
The development and growth of prostate cancer depends on the androgen receptor and its high-affinity binding of dihydrotestosterone, which derives from testosterone. Most prostate tumors regressExpand
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Cloning of human androgen receptor complementary DNA and localization to the X chromosome.
The androgen receptor (AR) mediates the actions of male sex steroids. Human AR genomic DNA was cloned from a flow-sorted human X chromosome library by using a consensus nucleotide sequence from theExpand
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The human androgen receptor: complementary deoxyribonucleic acid cloning, sequence analysis and gene expression in prostate.
Androgenic hormones mediate their effects on male sex differentiation and development through a high affinity receptor protein. We report here cloning of the complete coding sequence of the humanExpand
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Specificity of ligand-dependent androgen receptor stabilization: receptor domain interactions influence ligand dissociation and receptor stability.
The molecular basis for the different physiological effects of testosterone (T) and dihydrotestosterone (DHT) was investigated using recombinantly expressed wild-type and mutant androgen receptorExpand
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Transcriptional activation and nuclear targeting signals of the human androgen receptor.
The androgen receptor (AR) is a signal-transducing protein required for sexual differentiation, development, and expression of the male phenotype. A series of human AR deletion mutants were createdExpand
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Immunohistochemical localization of the androgen receptor in rat and human tissues.
Immunohistochemical localization of the androgen receptor (AR) was performed in reproductive tissues, submaxillary gland, pituitary, and brain of the rat and in human prostate. AR was visualizedExpand
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