• Publications
  • Influence
Glutamate: A Neurotransmitter in Mammalian Brain
  • F. Fonnum
  • Biology, Medicine
  • Journal of neurochemistry
  • 1 January 1984
TLDR
The evidence for glutamate as a transmitter at the locust neuromuscular junction has recently been carefully evaluated by Usherwood (1981), and it is shown that mechanisms exist that will terminate transmitter action rapidly. Expand
A rapid radiochemical method for the determination of choline acetyltransferase
  • F. Fonnum
  • Chemistry, Medicine
  • Journal of neurochemistry
  • 1 February 1975
TLDR
It is shown that the method for isolating labelled ACh by liquid cation exchange using sodium tetraphenylboron (Kalignost) in ethyl butyl ketone can be simplified considerably by using the scintillation mixture as extraction solvent and carrying out the extraction directly in theScintillation vial. Expand
Evaluation of the probes 2',7'-dichlorofluorescin diacetate, luminol, and lucigenin as indicators of reactive species formation.
TLDR
The results show that DCFH is oxidized to the fluorescent compound 2',7'-dichlorofluorescin diacetate (DCF) in human neutrophils exposed to the following compounds: Aroclor (A)1242, hydrogen peroxide (H(2)O(2)), nitric oxide (NO), and FeSO(4). Expand
Use of fluorocitrate and fluoroacetate in the study of brain metabolism
TLDR
Fluoroacetate and its toxic metabolite fluorocitrate cause inhibition of aconitase and it is the latter that has received most attention in the study of glial‐neuronal interactions, since glutamine is an important precursor for transmitter glutamate and GABA. Expand
An In Vivo Model for Studying Function of Brain Tissue Temporarily Devoid of Glial Cell Metabolism: The Use of Fluorocitrate
TLDR
The use of microinjection of 1 nmol of fluorocitrate into the neostria‐tum of the rat to provide a model for studying transmitter amino acid metabolism in brain devoid of glial cell activity is discussed. Expand
Selective inhibition of glial cell metabolism in vivo by fluorocitrate
TLDR
Differences in the labelling of gamma-aminobutyric acid (GABA) from [14C]acetate and citrate suggest that astrocytes associated with GABAergic and glutamatergic nerve terminals may differ in their preference for amino acid precursors. Expand
Radiochemical micro assays for the determination of choline acetyltransferase and acetylcholinesterase activities.
  • F. Fonnum
  • Chemistry, Medicine
  • The Biochemical journal
  • 1 November 1969
TLDR
The methods were tested with samples from central and peripheral nervous tissues and purified enzymes and the values of choline acetyltransferase activity obtained in the presence of sodium cyanide or EDTA and synthetic acetyl-CoA were similar to those obtained with acetyl -CoA synthesized in situ. Expand
The effect of brominated flame retardants on neurotransmitter uptake into rat brain synaptosomes and vesicles
TLDR
Hexabromocyclodododecane (HBCD) and tetrabromobisphenol-A (TBBPA) inhibit plasma membrane uptake of the neurotransmitter dopamine, glutamate and gamma-amino-n-butyric acid (GABA) at a concentration level similar to what previously found for polychlorinated biphenyls (PCBs) and even for ecstasy. Expand
Uptake of l‐Glutamate into Rat Brain Synaptic Vesicles: Effect of Inhibitors that Bind Specifically to the Glutamate Transporter
TLDR
The two most efficient inhibitors of the vesicular uptake of glutamate were the dyes Evans blue and Chicago Skye Blue 6B, which are structurally related to glutamate and were competitive inhibitors in the nanomolar range. Expand
In vitro toxicity of tetrabromobisphenol-A on cerebellar granule cells: cell death, free radical formation, calcium influx and extracellular glutamate.
TLDR
It is found that TBBPA induces ROS formation, increases intracellular calcium, extracellular glutamate, and death of CGC in vitro at concentrations comparable to those of polychlorinated biphenyl. Expand
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