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Angiotensin II inhibits insulin signaling in aortic smooth muscle cells at multiple levels. A potential role for serine phosphorylation in insulin/angiotensin II crosstalk.
- F. Folli, C. Kahn, H. Hansen, J. Bouchie, E. Feener
- Biology, Medicine
- The Journal of clinical investigation
- 1 November 1997
To investigate potential interactions between angiotensin II (AII) and the insulin signaling system in the vasculature, insulin and AII regulation of insulin receptor substrate-1 (IRS-1)… Expand
High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program.
Type 2 diabetes is characterized by insulin resistance and inadequate insulin secretion. In the advanced stages of the disease, beta-cell dysfunction worsens and insulin therapy may be necessary to… Expand
Insulin stimulation of phosphatidylinositol 3-kinase activity and association with insulin receptor substrate 1 in liver and muscle of the intact rat.
- F. Folli, M. J. Saad, J. Backer, C. Kahn
- Biology, Medicine
- The Journal of biological chemistry
- 5 November 1992
Growth factors stimulate the enzyme phosphatidylinositol (PI) 3-kinase in cells in culture. Insulin rapidly stimulates tyrosine phosphorylation of its endogenous substrate, insulin receptor substrate… Expand
Cross-talk between the insulin and angiotensin signaling systems.
- L. Velloso, F. Folli, X. J. Sun, M. White, M. J. Saad, C. Kahn
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 29 October 1996
Angiotensin II (AII), acting via its G-protein linked receptor, is an important regulator of cardiac, vascular, and renal function. Following injection of AII into rats, we find that there is also a… Expand
Hyperglycemia-induced oxidative stress and its role in diabetes mellitus related cardiovascular diseases.
- T. Fiorentino, A. Prioletta, P. Zuo, F. Folli
- Medicine, Biology
- Current pharmaceutical design
- 30 September 2013
Diabetes mellitus is associated to an increased risk of cardiovascular diseases. Hyperglycemia is an important factor in cardiovascular damage, working through different mechanisms such as activation… Expand
Insulin and insulin‐like growth factor‐1 stimulate proliferation and type I collagen accumulation by human hepatic stellate cells: Differential effects on signal transduction pathways
Insulin and insulin‐like growth factor (IGF‐1) are mitogenic for fibroblasts and smooth muscle cells. IGF‐1 increases in inflamed and fibrotic tissues and induces proliferation of rat hepatic… Expand
The inflammatory status score including IL-6, TNF-α, osteopontin, fractalkine, MCP-1 and adiponectin underlies whole-body insulin resistance and hyperglycemia in type 2 diabetes mellitus
A state of subclinical systemic inflammation is characteristically present in obesity/insulin resistance and type 2 diabetes mellitus (T2DM). The aim of the study was to develop an integrated measure… Expand
The multi‐faceted cross‐talk between the insulin and angiotensin II signaling systems
- L. Velloso, F. Folli, L. Perego, M. A. Saad
- Diabetes/metabolism research and reviews
- 1 March 2006
Insulin and angiotensin II are hormones that play pivotal roles in the control of two vital and closely related systems, the metabolic and the circulatory systems, respectively. A failure in the… Expand
Circulating Fibroblast Growth Factor-21 Is Elevated in Impaired Glucose Tolerance and Type 2 Diabetes and Correlates With Muscle and Hepatic Insulin Resistance
- A. Chávez, M. Molina-Carrión, M. Abdul-Ghani, F. Folli, R. DeFronzo, D. Tripathy
- Diabetes Care
- 1 June 2009
OBJECTIVE Fibroblast growth factor (FGF)-21 is highly expressed in the liver and regulates hepatic glucose production and lipid metabolism in rodents. However, its role in the pathogenesis of type 2… Expand
The role of nateglinide and repaglinide, derivatives of meglitinide, in the treatment of type 2 diabetes mellitus
- R. Guardado-Mendoza, Annamaria Prioletta, L. Jiménez-Ceja, A. Sosale, F. Folli
- Archives of medical science : AMS
- 30 April 2013
Type 2 diabetes mellitus (T2DM) is one of the most common chronic diseases worldwide, presenting a great challenge to the public health systems due to high morbidity and mortality, because of… Expand