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Mitochondrial BCL‐2 inhibits AMBRA1‐induced autophagy
BECLIN 1 is a central player in macroautophagy. AMBRA1, a BECLIN 1‐interacting protein, positively regulates the BECLIN 1‐dependent programme of autophagy. In this study, we show that AMBRA1 bindsExpand
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Up-regulation of p2x2, p2x4 receptor and ischemic cell death: prevention by p2 antagonists
In the present work we examined the involvement of selected P2X receptors for extracellular ATP in the onset of neuronal cell death caused by glucose/oxygen deprivation. The in vitro studies ofExpand
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N-Arachidonoyl-Dopamine Tunes Synaptic Transmission onto Dopaminergic Neurons by Activating both Cannabinoid and Vanilloid Receptors
In the present study, we used electrophysiological, biochemical, and confocal microscopy techniques, to investigate the functional role of transient receptor potential vanilloid type 1 (TRPV1) andExpand
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Selective CB2 Receptor Agonism Protects Central Neurons from Remote Axotomy-Induced Apoptosis through the PI3K/Akt Pathway
Endocannabinoids are neuroprotective in vivo and in vitro, but the mechanisms by which they act are largely unknown. The present study addressed the role of cannabinoid receptors during remote cellExpand
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Endogenous Aβ causes cell death via early tau hyperphosphorylation
Alzheimer's disease (AD) is characterized by Aβ overproduction and tau hyperphosphorylation. We report that an early, transient and site-specific AD-like tau hyperphosphorylation at Ser262 and Thr231Expand
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MDM4 (MDMX) localizes at the mitochondria and facilitates the p53‐mediated intrinsic‐apoptotic pathway
MDM4 is a key regulator of p53, whose biological activities depend on both transcriptional activity and transcription‐independent mitochondrial functions. MDM4 binds to p53 and blocks itsExpand
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APP is Phosphorylated by TrkA and Regulates NGF/TrkA Signaling
The pathogenic model of Alzheimer's disease (AD) posits that aggregates of amyloid β, a product of amyloid precursor protein (APP) processing, cause dementia. However, alterations of normal APPExpand
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Short- but not long-lasting treadmill running reduces allodynia and improves functional recovery after peripheral nerve injury
We analyzed the effects of different treadmill running protocols on the functional recovery after chronic constriction injury (CCI) of the sciatic nerve in mice. We found that a treadmill protocol ofExpand
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Morphological and bioenergetic demands underlying the mitophagy in post-mitotic neurons: the pink–parkin pathway
Evidence suggests a striking causal relationship between changes in quality control of neuronal mitochondria and numerous devastating human neurodegenerative diseases, including Parkinson’s disease,Expand
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AD-linked, toxic NH2 human tau affects the quality control of mitochondria in neurons
Functional as well as structural alterations in mitochondria size, shape and distribution are precipitating, early events in progression of Alzheimer's Disease (AD). We reported that a 20-22kDaExpand
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