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Preparation of sustained release apremilast-loaded PLGA nanoparticles: in vitro characterization and in vivo pharmacokinetic study in rats
TLDR
Bioavailability enhancement along-with long-term retention of the APM-loaded PLGA nanoparticles might be helpful for the once-daily regimen treatment. Expand
Genetic Diversity of Serum Proteins in Some Muslim Populations of India
TLDR
The allele frequency distribution of haptoglobin (HP) and transferrin (TF) phenotypes among the Muslims reveals genetic similarity among different immigrant populations, with the western population being the most distant. Expand
Olive Oil Based Organogels for Effective Topical Delivery of Fluconazole: In-vitro Antifungal Study
The objective of the study was to formulate olive oil based organogels for the topical application of fluconazole (FLZ), to ensure the efficient delivery of the drug deeper in to the skin layers.Expand
A Clinical Study of Vernal Keratoconjunctivitis
TLDR
VKC is a common form of allergic conjunctivitis in a tropical country like the authors' and it is a bilateral, recurrent debilitating form of disease found to affect young males below 16 years. Expand
Gastric bypass versus sleeve gastrectomy in patients with type 2 diabetes (Oseberg): a single-centre, triple-blind, randomised controlled trial.
TLDR
Gastric bypass was found to be superior to sleeve gastrectomy for remission of type 2 diabetes at 1 year after surgery, and the two procedures had a similar beneficial effect on β-cell function. Expand
Chitosan surface modified PLGA nanoparticles loaded with brigatinib for the treatment of non-small cell lung cancer
Abstract In the current study, surface-modified poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) of brigatinib (BRB) were prepared by studying the variables PLGA (polymer), PVA (stabilizer)Expand
Sustained release and enhanced oral bioavailability of rivaroxaban by PLGA nanoparticles with no food effect
TLDR
Compared to commercial tablet (XARELTO®), the RXB-PLGA-NPs (F8) exhibited a significant enhancement of bioavailability in both fasted and fed state and the bioavailability of RXB from NPs (f8) was found unaffected in the presence of food. Expand
Metabolic surgery: one size fits all? - Authors' reply.
TLDR
This work presents a novel and scalable approach called “SmartCardiovascular Intervention for Morbid Obesity” (SCI) that combines real-time, smartphone-based, 3D tracking and 3D image analysis for efficient and effective treatment of morbidly obese patients. Expand
Smart drug delivery systems: Thermo - pH responsive ciprofloxacin ophthalmic gels
TLDR
With such a systems one can increase the contact time of the drug with the localised site and increase bioavailabity which is normally desired for the treatment of ocular infection with ciprofloxacin Hcl. Expand
Solubility, solution thermodynamics and molecular interactions of osimertinib in some pharmaceutically useful solvents
Abstract A key factor in dosage form development is selection of a suitable solvent for the solubility of drugs. Solubility data of osimertinib (OSM) are scarce in the research literature. In currentExpand
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