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Hepatitis B virus maintains its pro-oncogenic properties in the case of occult HBV infection.
TLDR
Clear evidence is provided that occult HBV is a risk factor for development of HCC and that the potential mechanisms whereby overt HBV might induce tumor formation are mostly maintained in cases of occult infection. Expand
Transcatheter Arterial Chemoembolization (TACE) in Hepatocellular Carcinoma (HCC): The Role of Angiogenesis and Invasiveness
TLDR
When TACE is not totally effective, it may induce a significant neoangiogenetic reaction, as suggested by an increase in VEGF and b-FGF following treatment; this affects patient survival and antiangiogenic drugs may be indicated in TACE-treated HCC. Expand
Prospective validation of the Barcelona Clinic Liver Cancer staging system.
TLDR
In this cohort, BCLC had the best independent predictive power for survival when compared with the Okuda, CLIP, UNOS-T NM, and JIS prognostic systems and showed a better prognostic ability than the AJCC-TNM 2002 system in surgical patients. Expand
Iron storage, lipid peroxidation and glutathione turnover in chronic anti-HCV positive hepatitis.
TLDR
Findings suggest that hepatitis C virus-related liver damage is characterized by increased iron storage (possibly induced by the virus) which elicits a free-radical-mediated peroxidation, with consequent steatosis and activation of glutathione turnover, probably in response to free- radical-mediated liver damage. Expand
Rate of incidence of hepatocellular carcinoma in patients with compensated viral cirrhosis
TLDR
Patients with compensated cirrhosis of viral etiology diagnosed with hepatocellular carcinoma are evaluated for the rate of incidence of HCC in patients with compensated hepatitis B virus infection. Expand
Semiannual and annual surveillance of cirrhotic patients for hepatocellular carcinoma: effects on cancer stage and patient survival (Italian experience)
TLDR
Semiannual and annual surveillance equally improve the survival of cirrhotic patients with hepatocellular carcinoma and greatly increase the amenability rate to liver transplantation. Expand
Diagnostic and Prognostic Role of α-Fetoprotein in Hepatocellular Carcinoma: Both or Neither?
TLDR
The evaluation of this large series of HCC patients allowed us to confirm the low sensitivity of AFP in the diagnosis of H CC and its prognostic value, albeit limited, being tumor size, female sex, Child-Pugh score, and TNM staging independent predictors. Expand
Treatments for hepatocellular carcinoma in elderly patients are as effective as in younger patients: a 20-year multicentre experience
TLDR
The overall applicability of radical or effective HCC treatments was unaffected by old age, however, treatment distribution differed, elderly individuals being more frequently treated with percutaneous procedures and less frequently with resection or TACE. Expand
Diagnostic and prognostic role of alpha-fetoprotein in hepatocellular carcinoma: both or neither?
TLDR
The evaluation of this large series of HCC patients allowed us to confirm the low sensitivity of AFP in the diagnosis of H CC and its prognostic value, albeit limited, being tumor size, female sex, Child-Pugh score, and TNM staging independent predictors. Expand
Hepatitis C virus: from oxygen free radicals to hepatocellular carcinoma
TLDR
An overview of the inter‐relationships between HCV, liver damage, free radical production and HCC is provided, describing at least in part the complex network involving DNA oxidative damage, cytokine synthesis, proto‐oncogene activation and oestrogen receptor expression, that may all be deeply involved in liver carcinogenesis. Expand
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