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DGAT1 Is Not Essential for Intestinal Triacylglycerol Absorption or Chylomicron Synthesis*
- K. Buhman, Steven J Smith, Robert V Farese
- Biology, Computer ScienceThe Journal of Biological Chemistry
- 12 July 2002
Interestingly, DGAT1 was not essential for quantitative dietary triacylglycerol absorption, even in mice fed a high fat diet, or for the synthesis of chylomicrons, and analysis of intestine from Dgat1 −/−mice revealed activity for two other enzymes, DGat2 and diacyl glycerol transacylase, that catalyze triACYlglycersol synthesis and apparently help to compensate for the absence of DGAT 1.
Defective Fatty Acid Uptake in the Spontaneously Hypertensive Rat Is a Primary Determinant of Altered Glucose Metabolism, Hyperinsulinemia, and Myocardial Hypertrophy*
Genetic linkage studies implicated deficiency of CD36, a membrane fatty acid (FA) transporter, in the hypertriglyceridemia and hyperinsulinemia of the spontaneously hypertensive rat (SHR). In this…
Radioiodinated 15-(p-iodophenyl)-3,3-dimethylpentadecanoic acid: a useful new agent to evaluate myocardial fatty acid uptake.
- F. F. Knapp, M. Goodman, A. P. Callahan, G. Kirsch
- Chemistry, BiologyJournal of nuclear medicine : official…
- 1 April 1986
The greater myocardial retention and higher heart:blood ratios observed with DMIPP in comparison with both the 3-monomethyl-(BMIPP) and unbranched (IPP) analogs suggest that [123I]DMIPP is an excellent candidate for clinical evaluation of regional energy substrates (fatty acid) uptake.
New radioiodinated methyl-branched fatty acids for cardiac studies
It is suggested that the prolonged myocardial retention observed with DMIPP in vivo may result from inhibition of β oxidation, and [123I]DMIPP should be useful for evaluation of aberrations in regionalMyocardial uptake.
Processing of reactor-produced 188W for fabrication of clinical scale alumina-based 188W/188Re generators
The development of radioiodinated 3-methyl-branched fatty acids for evaluation of myocardial disease by single photon techniques
The measurement of regional myocardial “release-rates” after intravenous administration of iodine-123-labeled fatty acids such as 17-iodoheptadecanoic acid (HDA) [1–6] and…
Potential tissue-imaging agents: 23-(trimethyl [117mSn]stannyl)-24-nor-5 alpha-cholan-3 beta-ol.
- F. F. Knapp, A. P. Callahan, K. Ambrose, L. A. Ferren, T. Butler, J. L. Coffey
- Biology, MedicineJournal of medicinal chemistry
- 1 October 1983
Tin-117m-labeled 23-(trimethylstannyl)-24-nor-5 alpha-cholan-3 beta-ol has been prepared and may have potential as an adrenal imaging agent and the absorbed radiation dose values from [117mSn]2 to human organs have been estimated by using rat tissue distribution and excretion data.
The sterols and triterpenes of banana peel
Synthesis and evaluation of radioiodinated terminal p-iodophenyl-substituted alpha- and beta-methyl-branched fatty acids.
Results suggest that the mechanism of myocardial retention results from steric or chemical inhibition of the metabolism of these fatty acids by the presence of the methyl group.
Detection of cardiomyopathy in an animal model using quantitative autoradiography.
DMIPP seems to be a more sensitive indicator of early cardiomyopathic changes as compared to 201Tl or FDG, and the trial of DMIPP and SPECT in the diagnosis of human disease, as well as for monitoring the effects of drugs which may prevent it appears to be warranted.