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Kynurenines in the CNS: recent advances and new questions
This Review highlights the involvement of the kynurenine system in the pathology of neurodegenerative disorders, pain syndromes and autoimmune diseases through a detailed discussion of its potential implications in Huntington's disease, migraine and multiple sclerosis.
Effects of SEA0400 and KB-R7943 on Na+/Ca2+ exchange current and L-type Ca2+ current in canine ventricular cardiomyocytes
SEA0400 appears to be a suitable tool to study the role of INa/Ca in Ca2+ handling in canine cardiac cells and accelerated inactivation of ICa, retarded recovery from inactivation and shifted the voltage dependence of inactivation towards more negative voltages.
Changing the Face of Kynurenines and Neurotoxicity: Therapeutic Considerations
- Zsuzsanna Bohár, J. Toldi, F. Fülöp, L. Vécsei
- Biology, ChemistryInternational journal of molecular sciences
- 29 April 2015
Emerging knowledge about the kynurenine pathway provides new target points for the development of therapeutical solutions against neurodegenerative diseases.
Classic preconditioning decreases the harmful accumulation of nitric oxide during ischemia and reperfusion in rat hearts.
Although NO synthesis by the heart is necessary to trigger classic preconditionsing, preconditioning in turn attenuates the accumulation of NO during ischemia/reperfusion, and blockade of ischemIA/rePerfusion-induced accumulation of cardiac NO by precondITIONing or by an appropriate concentration of NOS inhibitor alleviates ischemian injury as demonstrated by enhanced postischemic function.
Salsolinol is a Putative Endogenous Neuro‐intermediate Lobe Prolactin‐Releasing Factor
The data clearly suggest that SAL is synthesized in situ and this compound can play a role in the regulation of pituitary prolactin secretion.
Kynurenines in chronic neurodegenerative disorders: future therapeutic strategies
- D. Zádori, P. Klivényi, E. Vámos, F. Fülöp, J. Toldi, L. Vécsei
- BiologyJournal of Neural Transmission
- 18 July 2009
The experimental data indicate that neuroprotection can be achieved by both alternatives, suggesting opportunities for further drug development in this field.
Mitochondrial disturbances, excitotoxicity, neuroinflammation and kynurenines: Novel therapeutic strategies for neurodegenerative disorders
Binding site of salsolinol: its properties in different regions of the brain and the pituitary gland of the rat
Liquid chromatographic enantioseparation of beta-blocking agents with (1R,2R)-1,3-diacetoxy-1-(4-nitrophenyl)-2-propyl isothiocyanate as chiral derivatizing agent.
Substituent cross-interaction effects on the electronic character of the C=N bridging group in substituted benzylidene anilines--models for molecular cores of mesogenic compounds. A 13C NMR study and…
The present NMR characteristics are discussed as regards the computational literature data and can be rationalized in terms of the substituent-sensitive balance of the electron delocalization (mesomeric effects).