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- Publications
- Influence
Kynurenines in the CNS: recent advances and new questions
- L. Vécsei, L. Szalardy, F. Fülöp, J. Toldi
- Biology, Medicine
- Nature Reviews Drug Discovery
- 2013
Various pathologies of the central nervous system (CNS) are accompanied by alterations in tryptophan metabolism. The main metabolic route of tryptophan degradation is the kynurenine pathway; its… Expand
Effects of SEA0400 and KB-R7943 on Na+/Ca2+ exchange current and L-type Ca2+ current in canine ventricular cardiomyocytes
- P. Birinyi, K. Acsai, +8 authors Péter P. Nánási
- Chemistry, Medicine
- Naunyn-Schmiedeberg's Archives of Pharmacology
- 6 August 2005
SEA0400 and KB-R7943 are compounds synthesised to block transsarcolemmal Na+/Ca2+ exchange current (INa/Ca); however, they Have also been shown to inhibit L-type Ca2+ current (ICa). The potential… Expand
Changing the Face of Kynurenines and Neurotoxicity: Therapeutic Considerations
- Zsuzsanna Bohár, J. Toldi, F. Fülöp, L. Vécsei
- Biology, Medicine
- International journal of molecular sciences
- 29 April 2015
Kynurenines are the products of tryptophan metabolism. Among them, kynurenine and kynurenic acid are generally thought to have neuroprotective properties, while 3-hydroxykynurenine,… Expand
Mitochondrial disturbances, excitotoxicity, neuroinflammation and kynurenines: Novel therapeutic strategies for neurodegenerative disorders
- D. Zádori, P. Klivényi, L. Szalardy, F. Fülöp, L. Vécsei
- Biology, Medicine
- Journal of the Neurological Sciences
- 15 November 2012
A mitochondrial dysfunction causes an abatement in ATP production, the induction of oxidative damage and the propagation of cell death pathways. It is additionally closely related to both glutamate… Expand
Classic preconditioning decreases the harmful accumulation of nitric oxide during ischemia and reperfusion in rat hearts.
- C. Csonka, Z. Szilvássy, +5 authors P. Ferdinandy
- Medicine
- Circulation
- 30 November 1999
BACKGROUND
The role of NO in the mechanism of preconditioning is not understood. Therefore, we studied the effect of preconditioning and subsequent ischemia/reperfusion on myocardial NO content in… Expand
Kynurenines in chronic neurodegenerative disorders: future therapeutic strategies
- D. Zádori, P. Klivényi, E. Vámos, F. Fülöp, J. Toldi, L. Vécsei
- Medicine
- Journal of Neural Transmission
- 18 July 2009
Parkinson’s, Alzheimer’s and Huntington’s diseases are chronic neurodegenerative disorders of a progressive nature which lead to a considerable deterioration of the quality of life. Their… Expand
Liquid chromatographic enantioseparation of beta-blocking agents with (1R,2R)-1,3-diacetoxy-1-(4-nitrophenyl)-2-propyl isothiocyanate as chiral derivatizing agent.
- M. Péter, Á. Gyéresi, F. Fülöp
- Chemistry, Medicine
- Journal of chromatography. A
- 2 March 2001
The applicability of (1R,2R)-1,3-diacetoxy-1-(4-nitrophenyl)-2-propyl isothiocyanate [(R,R)-DANI] as a recently developed chiral derivatizing agent for the enantioseparation of a series of… Expand
Neuroprotective effects of a novel kynurenic acid analogue in a transgenic mouse model of Huntington’s disease
- D. Zádori, G. Nyiri, +6 authors P. Klivényi
- Medicine
- Journal of Neural Transmission
- 1 June 2011
Huntington’s disease (HD) is a progressive neurodegenerative disorder, the pathomechanism of which is not yet fully understood. Excitotoxicity is known to be involved in the development of HD and… Expand
Neuroprotection with a new kynurenic acid analog in the four-vessel occlusion model of ischemia.
- L. Gellért, J. Fuzik, +8 authors J. Toldi
- Medicine
- European journal of pharmacology
- 30 September 2011
Global forebrain ischemia results in damage to the pyramids in the CA1 hippocampal subfield, which is particularly vulnerable to excitotoxic processes. Morphological and functional disintegration of… Expand
Electrophysiological effects of ivabradine in dog and human cardiac preparations: potential antiarrhythmic actions.
- I. Koncz, Tamás Szél, +11 authors A. Varró
- Chemistry, Medicine
- European journal of pharmacology
- 15 October 2011
Ivabradine is a novel antianginal agent which inhibits the pacemaker current. The effects of ivabradine on maximum rate of depolarization (V(max)), repolarization and spontaneous depolarization have… Expand