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Using voxel-based morphometry to map the structural changes associated with rapid conversion in MCI: A longitudinal MRI study
A novel longitudinal voxel-based method is used to map the progression of GM loss in MCI patients over time and compared converters to non-converters to better understand the pathological processes underlying AD and to monitor the effects of treatment on brain structure. Expand
Discrimination between Alzheimer Dementia and Controls by Automated Analysis of Multicenter FDG PET
A new diagnostic indicator of FDG PET scan abnormality, based on age-adjusted t statistics and an automated voxel-based procedure, is presented and validated in a large data set comprising 110 normalExpand
In Vivo Mapping of Gray Matter Loss with Voxel-Based Morphometry in Mild Alzheimer's Disease
This study has mapped gray matter density by means of voxel-based morphometry on T1-weighted MRI volume sets in 19 patients with mild AD and 16 healthy subjects of similar age and gender ratio and report highly significant clusters of gray matter loss with almost symmetrical distribution. Expand
Autobiographical memory and autonoetic consciousness: triple dissociation in neurodegenerative diseases.
It is demonstrated that autobiographical amnesia varies according to the nature of the memories under consideration and the locus of cerebral dysfunction, in the light of the two competing models of long-term memory consolidation and recent conceptions of autobiographical recollection. Expand
The structural components of music perception. A functional anatomical study.
Activations preferentially in the left hemisphere for familiarity, pitch tasks and rhythm, and in the right hemisphere for the timbre task are found, suggesting a role for this cerebral region in the processing of sequential sounds. Expand
Mapping gray matter loss with voxel-based morphometry in mild cognitive impairment
This pattern of gray matter loss in mild cognitive impairment agrees with but considerably expands upon previous region-of-interest based MRI studies, and is highly consistent with the course of neurofibrillary tangles across aging and Alzheimer's disease. Expand
Relationships between Hippocampal Atrophy, White Matter Disruption, and Gray Matter Hypometabolism in Alzheimer's Disease
It is found that hippocampal atrophy is specifically related to cingulum bundle disruption, which is in turn highly correlated to hypometabolism of the posterior cingulate cortex but also of the middle cingulates gyrus, thalamus, mammillary bodies, parahippocampal gyrus and hippocampus, as well as the right temporoparietal associative cortex. Expand
Voxel-based mapping of brain gray matter volume and glucose metabolism profiles in normal aging
The lesser affected anterior hippocampal region appears to mark the parting of the ways between normal aging and Alzheimer's disease, which is characterized by early and prominent deterioration of both structures. Expand
Episodic and semantic remote autobiographical memory in ageing
Assessment of age effects on autobiographical memory according to the length of the retention interval, taking into account the episodic and semantic components revealed that episodic recall deteriorated more with age and retention interval than semantic recall. Expand
Autobiographical memory, autonoetic consciousness, and self-perspective in aging.
Age-related differences were found for the specificity and spontaneity of memories and the phenomenal experience of remembering and the data support the view that older participants can subjectively "travel back in time" to relive personal events in the most distant past better than those in the recent past. Expand