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Increased Hypoxic Tolerance by Chemical Inhibition of Oxidative Phosphorylation: “Chemical Preconditioning”
A short ischemic episode preceding sustained ischemia is known to increase tolerance against ischemic cell death. We report early-onset long-lasting neuroprotection against in vitro hypoxia byExpand
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Linking Alterations in Tau Phosphorylation and Cleavage during Neuronal Apoptosis*
Neurofibrillary tangles (NFTs) are classic lesions of Alzheimer's disease. NFTs are bundles of abnormally phosphorylated tau, the paired helical filaments. The initiating mechanisms of NFTs and theirExpand
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Monozygotic twins concordant for blood karyotype, but phenotypically discordant: A case of “mosaic chimerism”
We report on 23 years old discordant monozygotic (MZ) twins, one with minor anomalies and mental delay, the other one being normal. Both had 46,XX,dup(11)(p12p15)/46,XX mosaicism in blood, with aExpand
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Baicalein protects cortical neurons from β-amyloid (25-35) induced toxicity
Accumulation of amyloid β peptide (Aβ) has been suggested to contribute to neurodegeneration in Alzheimer's disease (AD). Since chronic inflammation occurs in AD pathogenesis and lipoxygenases areExpand
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NMDA induces apoptosis and necrosis in neuronal cultures. Increased APP immunoreactivity is linked to apoptotic cells
In rat neuronal cultures exposed for a prolonged period (16 h) to a low concentration of N-methyl-D-aspartate (NMDA; 20 microM) two different types of neuronal death were observed, necrosis andExpand
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The presence of calbindin in rat cortical neurons protects in vitro from oxydative stress
Free radicals are highly reactive chemicals containing an unpaired electron and are normally produced by the cellular metabolism. The oxydative stress is defined as a lack of balance between theExpand
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Baicalein protects cortical neurons from beta-amyloid (25-35) induced toxicity.
Accumulation of amyloid beta peptide (Abeta) has been suggested to contribute to neurodegeneration in Alzheimer's disease (AD). Since chronic inflammation occurs in AD pathogenesis and lipoxygenasesExpand
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Toxic neuronal apoptosis and modifications of tau and APP gene and protein expressions.
The causes and the mechanisms of neuronal death in Alzheimer's disease are not elucidated, although some new insights have been proposed over the past years, including free-radical toxicity,Expand
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Neuroprotective effects of riluzole in ALS CSF toxicity.
Amyotrophic lateral sclerosis (ALS) is a neurological disorder neuropathologically characterized by a progressive degeneration of upper and lower motoneurons. The origin of the neuronal death isExpand
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Neurons overexpressing mutant presenilin‐1 are more sensitive to apoptosis induced by endoplasmic reticulum‐Golgi stress
Most early‐onset cases of familial Alzheimer's disease (FAD) are linked to mutations in two related genes, ps1 and ps2. FAD‐linked mutant PS1 alters proteolytic processing of the amyloid precursorExpand
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