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An evaluation of the male reproductive toxicity of cathinone.
It is concluded that the cathinone content in k Hat may be partially or totally responsible for the reproductive toxicity in khat chewers. Expand
Cytotoxicity of artemisinin-related endoperoxides to Ehrlich ascites tumor cells.
A series of artemisinin-related endoperoxides was tested for cytotoxicity to Ehrlich ascites tumor (EAT) cells using the microculture tetrazolium (MTT) assay. Artemisinin [1] had an IC50 value ofExpand
Antimicrobial activity of phenolic constituents of Magnolia grandiflora L.
Three phenolic constituents of Magnolia grandiflora L. were shown to possess significant antimicrobial activity using an agar well diffusion assay and the minimum inhibitory concentrations were determined. Expand
Bioactive 12-oleanene triterpene and secotriterpene acids from Maytenus undata.
The new 3,4-secotriterpene acid 20-epi-koetjapic acid (5) potently inhibited rat neonatal brain microglia phorbol ester-stimulated thromboxane B(2) and superoxide anion (IC(50) = 1.9 microM) generation. Expand
Antimycobacterial constituents from Juniperus procera, Ferula communis and Plumbago zeylanica and their in vitro synergistic activity with isonicotinic acid hydrazide
The synergistic activity of antimycobacterial constituents from Saudi plants was evaluated in combination with isonicotinic acid hydrazide (INH) against four atypical organisms, namely, MycobacteriumExpand
Abstract Three new carbazole alkaloids, 3-formyl-6-methoxycarbazole, methyl 6-methoxycarbazole-3-carboxylate and 3-formyl-1,6-dimethoxycarbazole and two carbazole derivatives, 3-formyl carbazole andExpand
Selection and micropropagation of high artemisinin producing clones of Artemisia annua L.
Results from unorganized callus cultures initiated from the leaves of the corresponding clones did not indicate the formation of artemisinin or related sesquiterpenes in these cultures. Expand
Cell culture assay system for the evaluation of natural product-mediated anti-Hepatitis B virus activity.
Utilizing the hepatitis B virus (HBV)-producing hepatoblastoma cell line, HepG2.2.15, which is stably transfected with the cloned HBV genome, methods were devised to examine the effects of testExpand
Artemisinin-derived sesquiterpene lactones as potential antitumour compounds: cytotoxic action against bone marrow and tumour cells.
We determined the in vitro cytotoxic activity of the sesquiterpene lactone endoperoxide artemisinin (1) and some chemically prepared derivatives, which have been found to display cytotoxicity toExpand
Cytotoxic sesquiterpene lactones from Centaurothamnus maximus and Vicoa pentanema
The aerial parts of Centaurothamnus maximus yielded three cytotoxic guaianolides, chlorojanerin (1), cynaropicrin (2) and janerin (3). The structure elucidation of 1–3 was based on 1H and 13C NMRExpand