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Evidence that Weakened Centromere Cohesion Is a Leading Cause of Age-Related Aneuploidy in Oocytes
Evidence That a Defective Spindle Assembly Checkpoint Is Not the Primary Cause of Maternal Age-Associated Aneuploidy in Mouse Eggs1
A natural reproductive aging mouse model is used to determine if a defective SAC is the primary cause of aneuploidy in eggs, and it is found that oocytes from old mice do not enter anaphase of meiosis I prematurely compared to young counterparts despite a 4-fold increase in the incidence ofAneuploids.
The γ isoform of CaM kinase II controls mouse egg activation by regulating cell cycle resumption
It is concluded that CaMKIIγ specifically controls mouse egg activation by regulating cell cycle resumption and requires elevated Ca2+i and metaphase II exit.
A bioprosthetic ovary created using 3D printed microporous scaffolds restores ovarian function in sterilized mice
These findings present an in vivo functional ovarian implant designed with 3D printing, and indicate that scaffold pore architecture is a critical variable in additively manufactured scaffold design for functional tissue engineering.
Reproductive age-associated fibrosis in the stroma of the mammalian ovary.
Fibrosis is established as an early hallmark of the aging ovarian stroma, and this altered microenvironment may contribute to the age-associated decline in gamete quality.
mTORC1/2 inhibition preserves ovarian function and fertility during genotoxic chemotherapy
- K. Goldman, D. Chenette, R. Schneider
- MedicineProceedings of the National Academy of Sciences
- 7 March 2017
It is shown that mTOR inhibition preserves the ovarian reserve, primordial follicle counts, serum anti-Mullerian hormone levels, and fertility, indicating a potentially effective and readily accessible pharmacologic approach to fertility preservation during conventional chemotherapy.
Chromosome Cohesion Decreases in Human Eggs with Advanced Maternal Age.
Aneuploidy in human eggs increases with maternal age and can result in infertility, miscarriages, and birth defects, which is largely unknown especially in the human where eggs are exceedingly rare and precious.
Isolated primate primordial follicles require a rigid physical environment to survive and grow in vitro.
By mimicking the rigid ovarian environment through the use of biomaterials, this work established conditions that support primordial follicle culture and lays the foundations for studying the basic biology ofPrimordial follicles in a controlled environment and for using primordial hair follicles for fertility preservation methods.
Future Directions in Oncofertility and Fertility Preservation: A Report from the 2011 Oncofertility Consortium Conference.
- Kate E. Waimey, F. Duncan, T. Woodruff
- MedicineJournal of adolescent and young adult oncology
- 7 March 2013
This summary from conference participants and leaders in the field addresses the science, clinical specialties, and academic scholarship that can guide the field as the Roadmap Grant funding comes to a close.
Maternally-derived zinc transporters ZIP6 and ZIP10 drive the mammalian oocyte-to-egg transition.
- B. Kong, F. Duncan, E. Que, A. Kim, T. O’Halloran, T. Woodruff
- BiologyMolecular human reproduction
- 1 November 2014
A mechanism of metal regulation required for female gamete development that may be evolutionarily conserved is demonstrated, as demonstrated by a lack of MTF-1 responsiveness to environmental zinc manipulation.