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Crystal structure of a ternary complex between human prostate-specific antigen, its substrate acyl intermediate and an activating antibody.
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Improving Escherichia coli Alkaline Phosphatase Efficacy by Additional Mutations inside and outside the Catalytic Pocket
TLDR
A strategy to confer on a bacterial (E. coli) alkaline phosphatase (AP) the high catalytic activity of the mammalian enzyme while maintaining its high thermostability was described.
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Genetic Engineering of Snake Toxins
TLDR
The previous and present mutational analysis suggest that the “functional” site of Ea covers a homogeneous surface of at least 680 A2, encompassing the three toxin loops, and includes both conserved and variant residues.
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High-resolution picture of a venom gland transcriptome: case study with the marine snail Conus consors.
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Crystal structure of the complex between the monomeric form of Toxoplasma gondii surface antigen 1 (SAG1) and a monoclonal antibody that mimics the human immune response.
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Crystal structure of human prostate-specific antigen in a sandwich antibody complex.
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Molecular evolution of snake toxins: is the functional diversity of snake toxins associated with a mechanism of accelerated evolution?
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Genetic engineering of snake toxins. Role of invariant residues in the structural and functional properties of a curaremimetic toxin, as probed by site-directed mutagenesis.
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Profiling the venom gland transcriptome of Tetramorium bicarinatum (Hymenoptera: Formicidae): the first transcriptome analysis of an ant species.
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Crystal Structure of a Hydrophobic Immunodominant Antigenic Site on Hepatitis C Virus Core Protein Complexed to Monoclonal Antibody 19D9D6 1
TLDR
The first crystal structure of a complex between a hepatitis C virus core protein-derived peptide and the Ab fragment of a murine mAb has been solved, allowing determination of the recognized epitope and elucidation of its conformation.
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