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Two different presynaptic calcium currents in mouse motor nerve terminals
Summary1.Extracellular recordings of potential changes under the perineural sheath of nerve bundles close to some of the nerve terminals were performed using the M. triangularis sterni of theExpand
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Dendrotoxin: a selective blocker of a non-inactivating potassium current in guinea-pig dorsal root ganglion neurones
Abstract1. The voltage clamp technique was used to study the effects of dendrotoxin (DTX) on outward potassium currents in internally perfused dorsal root ganglion neurones of guinea-pig. SodiumExpand
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Entry of alphaviruses at the plasma membrane converts the viral surface proteins into an ion-permeable pore that can be detected by electrophysiological analyses of whole-cell membrane currents.
Alphaviruses are small enveloped viruses that have been used extensively as model enveloped viruses. During infection, virus particles are taken up into endosomes, where a low pH activates the viralExpand
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Why Escherichia coli α‐hemolysin induces calcium oscillations in mammalian cells‐the pore is on its own
Escherichia coli α‐hemolysin (HlyA), archetype of a bacterial pore‐forming toxin, has been reported to deregulate physiological Ca2+ channels, thus inducing periodic low‐frequency Ca2+ oscillationsExpand
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At least three sequential steps are involved in the tetanus toxin-induced block of neuromuscular transmission
SummaryTetanus toxin causes a block of the neuromuscular transmission. The kinetic aspects of the block were studied in vitro on the mouse phrenic nerve-hemidiaphragm exposed to toxin (1 μg/ml). Expand
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Tetanus toxin blocks the neuromuscular transmission in vitro like botulinum a toxin
Summary1.The blocking effect of tetanus toxin on the neuromuscular junction of the mouse phrenic nervehemidiaphragm preparation exposed to the toxin (0.05–20 μg/ml) in the organ bath was studied andExpand
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Electrophysiological and neurobiochemical evidence for the blockade of a potassium channel by dendrotoxin
SummaryThe effects of dendrotoxin (DTX), a toxic peptide from Dendroaspis angusticeps venom, were studied electrophysiologically on peripheral frog nerve fibres, and biochemically on largeExpand
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Differential effects of various secretagogues on quantal transmitter release from mouse motor nerve terminals treated with botulinum A and tetanus toxin
Summary1.Electrophysiological and electron microscopic techniques were used to investigate the actions of potassium depolarization, black widow spider venom (BWSV), Ca2+-ionophore A 23187 andExpand
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Transmitter release in tetanus and botulinum A toxin-poisoned mammalian motor endplates and its dependence on nerve stimulation and temperature
The effects of tetanus toxin (TeTx) and botulinum A toxin (BoTx) on spontaneous and nerve-evoked transmitter release have been compared in mouse hemidiaphragms poisoned in vitro. At 37°C endplatesExpand
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The acetylcholine sensitivity in the vicinity of the neuromuscular junction of the frog
SummaryFor distancesr larger than 15 μm the ACh-response can be described by the diffusion law: the sensitivity depends onr−3; time to peak,T, and latency,L, depend onr2 (r=distanceExpand
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