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Disease modeling and phenotypic drug screening for diabetic cardiomyopathy using human induced pluripotent stem cells.
Diabetic cardiomyopathy is a complication of type 2 diabetes, with known contributions of lifestyle and genetics. We develop environmentally and genetically driven in vitro models of the conditionExpand
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Endothelin-1-stimulated InsP3-induced Ca2+ release is a nexus for hypertrophic signaling in cardiac myocytes.
Ca(2+) elevations are fundamental to cardiac physiology-stimulating contraction and regulating the gene transcription that underlies hypertrophy. How Ca(2+) specifically controls gene transcriptionExpand
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Regulated efflux of photoreceptor outer segment‐derived cholesterol by human RPE cells
Abstract Genetic studies have linked age‐related macular degeneration (AMD) to genes involved in high‐density lipoprotein (HDL) metabolism, including ATP‐binding cassette transporter A1 (ABCA1). TheExpand
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The role of the paracrine/autocrine mediator endothelin‐1 in regulation of cardiac contractility and growth
Endothelin‐1 (ET‐1) is a critical autocrine and paracrine regulator of cardiac physiology and pathology. Produced locally within the myocardium in response to diverse mechanical and neurohormonalExpand
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Mutual antagonism between IP3RII and miRNA-133a regulates calcium signals and cardiac hypertrophy
IP3RII-induced calcium release decreases miR-133a expression, which further increases IP3RII levels and calcium release and thereby promotes hypertrophic heart remodeling.
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The role of inflammation in diabetic eye disease
Mounting evidence suggests that immunological mechanisms play a fundamental role in the pathogenesis of diabetic retinopathy (DR) and diabetic macular edema (DME). Upregulation of cytokines and otherExpand
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Endothelin-1 promotes hypertrophic remodelling of cardiac myocytes by activating sustained signalling and transcription downstream of endothelin type A receptors
G-protein coupled receptor (GPCR) mediated activation of the MAPK signalling cascade is a key pathway in the induction of hypertrophic remodelling of the heart – a response to pathological cuesExpand
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Molecular Phenotyping Combines Molecular Information, Biological Relevance, and Patient Data to Improve Productivity of Early Drug Discovery.
Today, novel therapeutics are identified in an environment which is intrinsically different from the clinical context in which they are ultimately evaluated. Using molecular phenotyping and an inExpand
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Selective pharmacological inhibition of DDR1 prevents experimentally-induced glomerulonephritis in prevention and therapeutic regime
BackgroundDiscoidin domain receptor 1 (DDR1) is a collagen-activated receptor tyrosine kinase extensively implicated in diseases such as cancer, atherosclerosis and fibrosis. Multiple preclinicalExpand
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