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Role of Omega-3 Fatty Acids in the Treatment of Depressive Disorders: A Comprehensive Meta-Analysis of Randomized Clinical Trials
TLDR
Omega-3 PUFA resulted effective in RCTs on patients with bipolar disorder, whereas no evidence was found for those exploring their efficacy on depressive symptoms in young populations, perinatal depression, primary disease other than depression and healthy subjects. Expand
Identification of Dopamine D1–D3 Receptor Heteromers
TLDR
A main functional significance of the D3 receptor is to obtain a stronger dopaminergic response in the striatal neurons that co-express the two receptors. Expand
Fatty acid amide hydrolase (FAAH) inhibition enhances memory acquisition through activation of PPAR-alpha nuclear receptors.
TLDR
Using a passive-avoidance task in rats, it is found that memory acquisition was enhanced by the FAAH inhibitor URB597 or by the PPAR-alpha agonist WY14643, and these enhancements were blocked by thePPAR- alpha antagonist MK886. Expand
Omega-3 Fatty Acids and Depression: Scientific Evidence and Biological Mechanisms
TLDR
Tertiary prevention with omega-3 PUFA supplement in depressed patients has reached greater effectiveness during the last recent years, although definitive statements on their use in depression therapy cannot be yet freely asserted. Expand
Anxiolytic Effects in Mice of a Dual Blocker of Fatty Acid Amide Hydrolase and Transient Receptor Potential Vanilloid Type-1 Channels
TLDR
Simultaneous ‘indirect’ activation of CB1 receptors following FAAH inhibition, and antagonism at TRPV1 receptors might represent a new therapeutic strategy against anxiety. Expand
Endocannabinoids and β-amyloid-induced neurotoxicity in vivo: effect of pharmacological elevation of endocannabinoid levels
TLDR
It is suggested that early, as opposed to late, pharmacological enhancement of brain endocannabinoid levels might protect against β-amyloid neurotoxicity and its consequences. Expand
Depression and Alzheimer's disease: neurobiological links and common pharmacological targets.
TLDR
The evidence on the common molecular pathways between depression and Alzheimer's disease is examined and these pathways are discussed as new pharmacological targets for the treatment of both major depression and Alzheimers disease. Expand
Prenatal stress induces body weight deficit and behavioural alterations in rats: the effect of diazepam
TLDR
It is concluded that prenatal physical stress may induce bodygrowth retardation and may be considered as a model for human intrauterine growth retardation. Expand
Endocannabinoid system and mood disorders: priming a target for new therapies.
TLDR
The state of the art of the possible therapeutic use of endocannabinoid deactivation inhibitors and phytocannabinoids in mood disorders is discussed in this review article. Expand
Epigenetic Modulation of mGlu2 Receptors by Histone Deacetylase Inhibitors in the Treatment of Inflammatory Pain
TLDR
It is concluded that HDAC inhibition produces analgesia by up-regulating mGlu2 receptor expression in the DRG, an effect that results from the amplification of NF-κB transcriptional activity. Expand
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