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Stealth liposomes: review of the basic science, rationale, and clinical applications, existing and potential
Among several promising new drug-delivery systems, liposomes represent an advanced technology to deliver active molecules to the site of action, and at present several formulations are in clinicalExpand
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Preparation, characterization and properties of sterically stabilized paclitaxel-containing liposomes.
Paclitaxel (Taxol) is a diterpenoid isolated from Taxus brevifolia, approved by the FDA for the treatment of ovarian and breast cancers. Due to its low solubility in water, it is clinicallyExpand
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Preparation, characterization, cytotoxicity and pharmacokinetics of liposomes containing docetaxel.
The taxanes, paclitaxel and docetaxel, are anticancer agents used in clinical trials against ovarian carcinoma, breast, lung and head/neck cancer. Paclitaxel, very insoluble in water, is generallyExpand
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Solid lipid nanoparticles as vehicles of drugs to the brain: current state of the art.
Central nervous system disorders are already prevalent and steadily increasing among populations worldwide. However, most of the pharmaceuticals present on world markets are ineffective in treatingExpand
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Immunotoxins and Anticancer Drug Conjugate Assemblies: The Role of the Linkage between Components
Immunotoxins and antibody-drug conjugates are protein-based drugs combining a target-specific binding domain with a cytotoxic domain. Such compounds are potentially therapeutic against diseasesExpand
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EC-145, a folate-targeted Vinca alkaloid conjugate for the potential treatment of folate receptor-expressing cancers.
EC-145, under development by Endocyte, is a conjugate composed of desacetylvinblastine monohydrazide linked through a peptide spacer to the targeting moiety folic acid, for the potential intravenousExpand
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A unique squalenoylated and nonpegylated doxorubicin nanomedicine with systemic long-circulating properties and anticancer activity
Significance We identified that the chemical linkage of the anticancer drug doxorubicin onto squalene, a natural lipid precursor of the cholesterol’s biosynthesis, led to the formation of squalenoylExpand
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Hyaluronic acid for anticancer drug and nucleic acid delivery.
Hyaluronic acid (HA) is widely used in anticancer drug delivery, since it is biocompatible, biodegradable, non-toxic, and non-immunogenic; moreover, HA receptors are overexpressed on many tumorExpand
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PEGylation of proteins and liposomes: a powerful and flexible strategy to improve the drug delivery.
PEGylation is one of the most successful strategies to improve the delivery of therapeutic molecules such as proteins, macromolecular carriers, small drugs, oligonucleotides, and other biomolecules.Expand
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Preparation, characterization and properties in vitro and in vivo of a paclitaxel–albumin conjugate
Paclitaxel (taxol) is in routine clinical use for treatment of a variety of cancers. Because of its low aqueous solubility, it requires Cremophor EL (polyethoxylated castor oil) and ethanol as aExpand
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