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The RNA helicases p68/p72 and the noncoding RNA SRA are coregulators of MyoD and skeletal muscle differentiation.
Reducing the levels of p68/p72 proteins impaired recruitment of the TATA binding protein TBP; RNA polymerase II; and the catalytic subunit of the ATPase SWI/SNF complex, Brg-1, and hindered chromatin remodeling. Expand
Pax7 activates myogenic genes by recruitment of a histone methyltransferase complex
A multi-level approach to define the role of Pax7 in satellite cell function revealed that Pax7 induces chromatin modifications that stimulate transcriptional activation of target genes to regulate entry into the myogenic developmental programme. Expand
cDNA Cloning of Human Retinoic Acid-metabolizing Enzyme (hP450RAI) Identifies a Novel Family of Cytochromes P450 (CYP26)*
It is demonstrated that hP450RAI is responsible for generation of several hydroxylated forms of RA, including 4-OH, 4-oxo-RA, and 18-OH-RA and concluded that this enzyme plays a key role in RA metabolism, functioning in a feedback loop where RA levels are controlled in an autoregulatory manner. Expand
Identification of the Retinoic Acid-inducible All-trans-retinoic Acid 4-Hydroxylase*
P450RAI represents the first enzymatic component of RA metabolism to be isolated and characterized at the molecular level and provides key insight into regulation of retinoid homeostasis. Expand
Differential genomic targeting of the transcription factor TAL1 in alternate haematopoietic lineages
A critical role of the cellular environment in modulating transcription factor binding is highlighted, and insight is provided into the mechanism by which TAL1 inhibits differentiation leading to oncogenesis in the T‐cell lineage. Expand
p38 MAPK signaling regulates recruitment of Ash2L-containing methyltransferase complexes to specific genes during differentiation
It is demonstrated that developmentally regulated genes become epigenetically marked for gene expression during muscle differentiation through specific recruitment of Ash2L-containing methyltransferase complexes, providing evidence that signaling pathways regulate the targeting of TrxG-mediated epigenetic modifications at specific promoters during cellular differentiation. Expand
PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator.
We show that PARP-1 is indispensable to retinoic acid receptor (RAR)-mediated transcription from the RARbeta2 promoter in a highly purified, reconstituted transcription system and that RA-inducibleExpand
Tissue-specific splicing of a ubiquitously expressed transcription factor is essential for muscle differentiation.
The results reveal a novel mechanism in which a tissue-specific alternate splicing event has evolved that permits a ubiquitously expressed transcription factor to escape inhibitory signaling for temporal regulation of gene expression. Expand
Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription
A possible sequential mechanism for ligand-dependent transcriptional activation by nuclear receptors is presented and the in vitro and in vivo data that support this model are discussed. Expand