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Platelet Releasate Proteome Profiling Reveals a Core Set of Proteins with Low Variance between Healthy Adults
Taken together, the PR contains valuable soluble and vesicular cargo and has low‐population variance among healthy adults, rendering it a potentially useful platform for diagnostic fingerprinting of platelet‐related disease.
Platelet Derived Exosomes Are Enriched for Specific microRNAs Which Regulate WNT Signalling in Endothelial Cells
By transfecting miRs into endothelial cells they specifically modulated the cytosolic and nuclear expression of beta-catenin affecting tight junction formation and cell motility and it is demonstrated that these platelet exosomal miRNAs can regulate WNT signalling in endothelial Cells.
Proteomic signatures of antiplatelet drugs: new approaches to exploring drug effects
- S. Marcone, F. Dervin, D. Fitzgerald
- Biology, MedicineJournal of thrombosis and haemostasis : JTH
- 1 June 2015
The application of proteomic analysis is looked at, an approach that provides an integrated readout of these diverse influences that explain a wide variability in platelet response to antiplatelet drugs.
Human Platelet Exosome Proteomics Leads to the Identification of WNT Positive Exosomes Which Impact Canonical WNT Signalling in Target Cells
The proteomic analysis has revealed that platelet exosomes are new players in the regulation of WNT signalling in both endothelial and monocytic cells, both cell types closely linked to the pathogenesis of atherosclerosis.