• Publications
  • Influence
Disposition of Caspofungin: Role of Distribution in Determining Pharmacokinetics in Plasma
ABSTRACT The disposition of caspofungin, a parenteral antifungal drug, was investigated. Following a single, 1-h, intravenous infusion of 70 mg (200 μCi) of [3H]caspofungin to healthy men, plasma,Expand
  • 108
  • 8
  • PDF
Effect of Dexamethasone on the Intestinal First-Pass Metabolism of Indinavir in Rats: Evidence of Cytochrome P-450 A and p-Glycoprotein Induction
Indinavir, a potent and specific inhibitor of HIV protease, is a known substrate of cytochrome P-450 (CYP) 3A and p-glycoprotein. The purpose of this study is to investigate and compare the inducingExpand
  • 76
  • 6
  • PDF
On the absorption of alendronate in rats.
Alendronate is an antiosteolytic agent under investigation for the treatment of a number of bone disorders. Since the compound is a zwitterion with five pKa values and is completely ionized in theExpand
  • 71
  • 3
Timolol metabolism in man and laboratory anamals.
The two major urinary metabolites of 14C-timolol in man, involving oxidation and hydrolytic cleavage of the morpholine ring, are also observed in both Sprague-Dawley rats and CRCD-1 mice. These areExpand
  • 22
  • 3
Nonlinear pharmacokinetics of efavirenz (DMP-266), a potent HIV-1 reverse transcriptase inhibitor, in rats and monkeys.
Efavirenz (EFV, Sustiva, Stocrin, DMP-266, L-743,726) is a potent and selective non-nucleoside inhibitor of HIV-1 reverse transcriptase. Pharmacokinetics of EFV was studied in rats and monkeys, theExpand
  • 40
  • 3
  • PDF
Effect of dexamethasone on the intestinal first-pass metabolism of indinavir in rats: evidence of cytochrome P-450 3A [correction of P-450 A] and p-glycoprotein induction .
Indinavir, a potent and specific inhibitor of HIV protease, is a known substrate of cytochrome P-450 (CYP) 3A and p-glycoprotein. The purpose of this study is to investigate and compare the inducingExpand
  • 23
  • 2
The physiological disposition and metabolism of enalapril maleate in laboratory animals.
N-[1-(S)-carboxy-3-phenylpropyl]-L-alanyl-L-proline (MK-422), is a potent angiotensin I-converting enzyme (ACE) inhibitor, but as a diacid is poorly absorbed in laboratory animals. Enalapril maleate,Expand
  • 130
  • 1
Electron-capture GLC determination of timolol in human plasma and urine.
A GLC procedure was developed for measuring nanogram quantities of timolol in plasma and urine. The unchanged drug was extracted into heptane-4% isoamyl alcohol from alkalinized plasma or urine,Expand
  • 39
  • 1
Interspecies differences in stereoselective protein binding and clearance of MK-571.
(+)-3-(((3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)((3-(dimethylamino)- 3-oxopropyl)thio)methyl)thio)propanoic acid (MK-571), is a potent and specific antagonist of leukotriene D4 action in vitroExpand
  • 27
  • 1
Metabolites of caspofungin acetate, a potent antifungal agent, in human plasma and urine.
  • S. Balani, X. Xu, +13 authors T. Baillie
  • Chemistry, Medicine
  • Drug metabolism and disposition: the biological…
  • 1 November 2000
Caspofungin acetate (MK-0991) is a semisynthetic pneumocandin derivative being developed as a parenteral antifungal agent with broad-spectrum activity against systemic infections such as those causedExpand
  • 94
  • 1
  • PDF