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Interventions for alopecia areata.
TLDR
No RCTs were found on the use of diphencyprone, dinitrochlorobenzene, intralesional corticosteroids or dithranol although they are commonly used for the treatment of alopecia areata.
Drugs for discoid lupus erythematosus.
TLDR
Fluocinonide cream may be more effective than hydrocortisone in treating people with discoid lupus erythematosus, and hydroxychloroquine and acitretin appear to be of equal efficacy, although adverse effects are more frequent and more severe with acitRETin.
Interventions for prevention of herpes simplex labialis (cold sores on the lips).
TLDR
The quality of the body of evidence was low to moderate for most outcomes, but was very low for a few outcomes, and the direction of intervention effect was unrelated to the risk of bias.
Dietary exclusions for established atopic eczema.
TLDR
Little evidence supports the use of various exclusion diets in unselected people with atopic eczema, but that may be because they were not allergic to those substances in the first place.
Scoping systematic review of treatments for eczema
TLDR
There was reasonable evidence of benefit for the topical medications tacrolimus, pimecrolimus and various corticosteroids for both treatment and flare prevention, but additional research evidence is needed for emollients, bath additives, antibacterials, specialist clothing and complementary and alternative therapies.
Dietary exclusions for improving established atopic eczema in adults and children: systematic review
TLDR
A systematic review of randomized controlled trials to assess the effects of dietary exclusions for the treatment of established atopic eczema finds little good quality evidence to support the use of exclusion diets in atopic Eczema.
Tumour necrosis factor alpha in severe congestive cardiac failure.
TLDR
The stimulus resulting in enhanced plasma concentrations of TNF alpha in congestive heart failure remains unclear and concentrations at any particular time were not prognostic.
What is the evidence base for atopic eczema treatments? A summary of published randomized controlled trials
TLDR
An overview of the updated NIHR Health Technology Assessment systematic review of AE treatments is presented, finding ‘reasonable evidence of benefit’ for corticosteroids, calcineurin inhibitors, Atopiclair®, ciclosporin, azathioprine, ultraviolet radiation and education programmes.
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