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The Medicago Genome Provides Insight into the Evolution of Rhizobial Symbioses
TLDR
The draft sequence of the M. truncatula genome sequence is described, a close relative of alfalfa (Medicago sativa), a widely cultivated crop with limited genomics tools and complex autotetraploid genetics, which provides significant opportunities to expand al falfa’s genomic toolbox. Expand
NSP1 of the GRAS Protein Family Is Essential for Rhizobial Nod Factor-Induced Transcription
TLDR
The identification of the Medicago GRAS-type protein Nodulation signaling pathway 1 (NSP1), which is essential for all known Nod factor–induced changes in gene expression, is reported. Expand
A Putative Ca2+ and Calmodulin-Dependent Protein Kinase Required for Bacterial and Fungal Symbioses
TLDR
DMI3, a Medicago truncatula gene that acts immediately downstream of calcium spiking in this signaling pathway and is required for both nodulation and mycorrhizal infection, has high sequence similarity to genes encoding calcium and calmodulin-dependent protein kinases (CCaMKs). Expand
Rhizobium meliloti lipooligosaccharide nodulation factors: different structural requirements for bacterial entry into target root hair cells and induction of plant symbiotic developmental responses.
TLDR
Rhizobium meliloti produces lipochitooligosaccharide nodulation NodRm factors, which are clearly more stringent for bacterial entry than for the elicitation of developmental plant responses. Expand
An integrated analysis of plant and bacterial gene expression in symbiotic root nodules using laser-capture microdissection coupled to RNA sequencing.
TLDR
This study, focused on the association between the model legume Medicago truncatula and its symbiont Sinorhizobium meliloti, led to the production of 942 million sequencing read pairs that were unambiguously mapped on plant and bacterial genomes. Expand
Medicago truncatula DMI1 Required for Bacterial and Fungal Symbioses in Legumes
TLDR
The DMI1 (does not make infections) gene encodes a novel protein with low global similarity to a ligand-gated cation channel domain of archaea that is highly conserved in angiosperms and ancestral to land plants. Expand
Aristolochic acid nephropathy: a worldwide problem.
TLDR
The incidence of Aristolochic acid nephropathy is probably much higher than initially thought, especially in Asia and the Balkans, and despite the Food and Drug Administration's warnings concerning the safety of botanical remedies containing AA, these herbs are still sold via the Internet. Expand
Rhizobium lipo-chitooligosaccharide nodulation factors: signaling molecules mediating recognition and morphogenesis.
TLDR
This review summarizes the current knowledge on the biosynthesis, structure, and function of this new class of signaling molecules and discusses the possibility that these signals could be part of a new family of plant lipo-chitooligosaccharide growth regulators. Expand
Molecular basis of symbiotic host specificity in rhizobium meliloti: nodH and nodPQ genes encode the sulfation of lipo-oligosaccharide signals
TLDR
Results provide strong evidence that the molecular mechanism by which the nodH and nodPQ genes mediate host specificity is by determining the sulfation of the extracellular Nod signals. Expand
Legume genome evolution viewed through the Medicago truncatula and Lotus japonicus genomes
TLDR
S synteny, synonymous substitutions and phylogenetic analyses are described to identify and date a probable whole-genome duplication event predating speciation in Medicago or Lotus, with no direct evidence for any recent large-scale genome duplication. Expand
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