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Human Mesenchymal Stem Cells Inhibit Neutrophil Apoptosis: A Model for Neutrophil Preservation in the Bone Marrow Niche
Mesenchymal stem cells (MSC) establish close interactions with bone marrow sinusoids in a putative perivascular niche. These vessels contain a large storage pool of mature nonproliferating… Expand
Soluble Fas ligand is chemotactic for human neutrophilic polymorphonuclear leukocytes.
- L. Ottonello, G. Tortolina, M. Amelotti, F. Dallegri
- Medicine, Biology
- Journal of immunology
- 15 March 1999
It has been recently shown that Fas ligand (FasL) expression on islet beta grafts results in neutrophilic infiltration and graft rejection. In this study, we show that human recombinant soluble FasL… Expand
CC and CXC chemokines are pivotal mediators of cerebral injury in ischaemic stroke.
- M. Mirabelli-Badenier, V. Braunersreuther, +5 authors F. Montecucco
- Thrombosis and haemostasis
- 21 December 2010
The definition of ischaemic stroke has been recently updated as an acute episode of neurological dysfunction caused by focal brain, spinal cord, or retinal ischaemia in the presence of a cerebral… Expand
Tumor necrosis factor-alpha (TNF-alpha) induces integrin CD11b/CD18 (Mac-1) up-regulation and migration to the CC chemokine CCL3 (MIP-1alpha) on human neutrophils through defined signalling pathways.
Strong evidence suggests that neutrophils may play an active role in acute and chronic inflammatory disorders, such as rheumatoid arthritis and atherosclerosis. Given the role of pro-inflammatory… Expand
Tissue injury in neutrophilic inflammation
Abstract. The exudation of neutrophils is the hallmark of a form of inflammatory response occurring after tissue colonization by invading bacteria or as an expression of various non-infectious… Expand
Synovial fluid from patients with rheumatoid arthritis inhibits neutrophil apoptosis: role of adenosine and proinflammatory cytokines.
OBJECTIVE In synovial fluid (SF) from patients with rheumatoid arthritis (RA), neutrophils are exposed to proinflammatory mediators endowed with either anti-apoptotic or pro-apoptotic properties. We… Expand
Induction of Neutrophil Chemotaxis by Leptin
- F. Montecucco, G. Bianchi, P. Gnerre, M. Bertolotto, F. Dallegri, L. Ottonello
- Biology, Medicine
- Annals of the New York Academy of Sciences
- 1 June 2006
Abstract: Leptin is involved in energy homeostasis, hematopoiesis, inflammation, and immunity. Although hypoleptinemia characterizing malnutrition has been strictly related to increased… Expand
CCL19 and CXCL12 Trigger in Vitro Chemotaxis of Human Mantle Cell Lymphoma B Cells
- A. Corcione, N. Arduino, +9 authors V. Pistoia
- Biology, Medicine
- Clinical Cancer Research
- 1 February 2004
Purpose: Few data are available in the literature on chemokine receptor expression and migratory capability of mantle cell lymphoma (MCL) B cells. Information on these issues may allow us to identify… Expand
CCL3 (MIP-1alpha) induces in vitro migration of GM-CSF-primed human neutrophils via CCR5-dependent activation of ERK 1/2.
- L. Ottonello, F. Montecucco, +5 authors F. Dallegri
- Chemistry, Medicine
- Cellular signalling
- 1 March 2005
CCL3 (MIP-1alpha), a prototype of CC chemokines, is a potent chemoattractant toward human neutrophils pre-treated with GM-CSF for 15 min. GM-CSF-treated neutrophils migrate also to the selective CCR5… Expand
Taurine Prevents Apoptosis Induced by High Ambient Glucose in Human Tubule Renal Cells
- D. Verzola, M. Bertolotto, +7 authors G. Deferrari
- Biology, Medicine
- Journal of Investigative Medicine
- 1 November 2002
Background Hyperglycemia selectively triggers apoptosis in tubule and endothelial cells. Taurine, a conditionally essential amino acid, is abundant in several tubule segments, but its role has not… Expand