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Phenotypic expression in double heterozygotes for familial hypercholesterolemia and familial defective apolipoprotein B‐100
These cases refer to a new class of patients with digenic lipid disorders, defined by specific clinical features that result from the combined effects of two independent loci, giving insight into the molecular mechanisms that underly the clinical variability of inherited hypercholesterolemia.
Screening for new mutations in the LDL receptor gene in seven French familial hypercholesterolemia families by the single strand conformation polymorphism method
The results indicate that the SSCP analysis of amplified genomic DNA fragments can be successfully used to rapidly screen mutation containing exons in large genes and demonstrate heterogeneity of LDLR gene mutations responsible for FH in the French population, as in other reported Caucasian populations.
Coagulation factor VII and plasma triglycerides. Decreased catabolism as a possible mechanism of factor VII hyperactivity.
The deficient postprandial catabolism of triglycerides appears to be related to an increase in total FVII concentration, suggesting that some association between the metabolism of triglyceride-rich lipoproteins and FVII might underlie the mechanism of the elevation in FVII.
Lipid Profile and Antihypertensive Efficacy in Hyperlipidemic Hypertensive Patients: Comparison of Rilmenidine and Captopril
Evidence is provided that over a follow-up period of 8 weeks, both RIL and CAP are efficient and well-tolerated drugs in the first-line treatment of hypertensive patients with lipid abnormalities.
Coagulation Factor VII and Plasma Triglycerides
High circulating levels of coagulation factor VII (FVII) are known to be associated with elevated concentrations of blood lipids. More specifically, hypertriglyceridemia is correlated with raised FVII
Blood antioxidants (vitamin E and beta-carotene) in long-term low density lipoprotein apheresis.
- U. Assogba, S. Lepage, +4 authors J. Delattre
- Chemistry, MedicineClinica chimica acta; international journal of…
- 31 March 1995
This study shows that patients with familial hypercholesterolaemia exhibited no deficiency in either serum of VLDL-LDL of vitamin E or beta-carotene after long-term treatment by LDL-apheresis and that the status of these antioxidants in serum was independent of the duration of treatment.
Usefulness in predicting coronary artery disease by ultrasonic evaluation of the carotid arteries in asymptomatic hypercholesterolemic patients with positive exercise stress tests.
The combination of clinical, electrical, and echographic data facilitates cost-effective noninvasive detection of CAD in asymptomatic hypercholesterolemic patients and significantly improved the diagnostic specificity of exercise electrocardiography.
Carotid stenosis is a powerful predictor of a positive exercise electrocardiogram in a large hyperlipidemic population.
It is concluded that hyperlipidemic patients with atherosclerotic lesions on carotid arteries would benefit most from screening by the exercise ECG.
Lipoprotein glomerulopathy: first case in a white European.
- A. Meyrier, F. Dairou, P. Callard, B. Mougenot
- MedicineNephrology, dialysis, transplantation : official…
- 1 April 1995
The first case of LG in a white European with no such lipid abnormalities is reported, suggesting that LG is a local glomerular, not a general lipid disorder and indicates that this disease is not restricted to Asian patients.