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Pain perception is altered by a nucleotide polymorphism in SCN9A
- F. Reimann, J. Cox, +22 authors C. Woods
- Proceedings of the National Academy of Sciences
- 8 March 2010
The gene SCN9A is responsible for three human pain disorders. Nonsense mutations cause a complete absence of pain, whereas activating mutations cause severe episodic pain in paroxysmal extreme pain… Expand
Tofacitinib for the treatment of severe alopecia areata and variants: A study of 90 patients
Background: Alopecia areata (AA) is a common autoimmune disorder. There are no reliably effective therapies for AA. Objective: We sought to evaluate the safety and efficacy of the Janus kinase 1/3… Expand
Association of catechol-O-methyltransferase genetic variants with outcome in patients undergoing surgical treatment for lumbar degenerative disc disease.
- F. Dai, I. Belfer, +6 authors D. Kim
- The spine journal : official journal of the North…
- 1 November 2010
BACKGROUND CONTEXT Surgical treatment for lumbar degenerative disc disease (DDD) has been associated with highly variable results in terms of postoperative pain relief and functional improvement.… Expand
Association of Provider Specialty and Multidisciplinary Care With Hepatocellular Carcinoma Treatment and Mortality.
BACKGROUND & AIMS Little is known about provider and health system factors that affect receipt of active therapy and outcomes of patients with hepatocellular carcinoma (HCC). We investigated patient,… Expand
Emotional intelligence and the relationship to resident performance: a multi-institutional study.
STUDY OBJECTIVE To test the hypothesis that emotional intelligence, as measured by a BarOn Emotional Quotient Inventory (EQ-i), the 125-item version personal inventory (EQ-i:125), correlates with… Expand
Integration of pain score and morphine consumption in analgesic clinical studies.
- F. Dai, D. Silverman, J. Chelly, J. Li, I. Belfer, Li Qin
- The journal of pain : official journal of the…
- 1 August 2013
UNLABELLED In pain clinical trials, the rescue analgesic medication such as patient-controlled analgesia morphine is often made available for patients for breakthrough pain. The patient-controlled… Expand
Phenotyping and Genotyping Neuropathic Pain
Despite ongoing efforts, neither effective treatments nor mechanistic understanding of the pathogenesis of human neuropathic pain exists. Genetic association studies may point to the novel molecules… Expand
Development and Performance of an Algorithm to Estimate the Child-Turcotte-Pugh Score From a National Electronic Healthcare Database.
- D. Kaplan, F. Dai, +11 authors T. Taddei
- Clinical gastroenterology and hepatology : the…
- 1 December 2015
BACKGROUND & METHODS The Child-Turcotte-Pugh (CTP) score is a widely used and validated predictor of long-term survival in cirrhosis. The CTP score is a composite of 5 subscores, 3 based on objective… Expand
Blunted rise in brain glucose levels during hyperglycemia in adults with obesity and T2DM.
In rodent models, obesity and hyperglycemia alter cerebral glucose metabolism and glucose transport into the brain, resulting in disordered cerebral function as well as inappropriate responses to… Expand
Handoffs in the Postoperative Anesthesia Care Unit: Use of a Checklist for Transfer of Care.
Information loss can occur during all phases of care. The transfer of care (handoff) from the operating room to the postoperative anesthesia care unit (PACU) is an especially susceptible time.… Expand