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Hand2 determines the noradrenergic phenotype in the mouse sympathetic nervous system.
TLDR
The data suggest that the major role of Hand2 during SNS development is to permit sympathetic neurons to acquire a catecholaminergic phenotype, which is not essential for SNS neuronal differentiation. Expand
Bone Morphogenetic Protein-2 and -4 Limit the Number of Enteric Neurons But Promote Development of a TrkC-Expressing Neurotrophin-3-Dependent Subset
TLDR
BMP-2 and/or BMP-4 thus limit the size of the ENS but promote the development of specific subsets of enteric neurons, including those that express TrkC, when applied to immunopurified E12 ENS precursors. Expand
The retrotrapezoid nucleus neurons expressing Atoh1 and Phox2b are essential for the respiratory response to CO2
TLDR
Here, intersectional genetic strategies to lesion the RTN neurons defined by Atoh1 and Phox2b expression and to block or activate their synaptic output are used and it is shown that photostimulation of these neurons entrains the respiratory rhythm and abolishes the respiratory chemoreflex in behaving animals. Expand
Ongoing roles of Phox2 homeodomain transcription factors during neuronal differentiation
TLDR
Cases where the neuronal differentiation program does not unfold as a transcriptional `cascade' whereby downstream events are irreversibly triggered by an upstream regulator, but instead require continuous transcriptional input from it are illustrated. Expand
Homeoprotein Phox2b commands a somatic-to-visceral switch in cranial sensory pathways
TLDR
The cranial sensory pathways, somatic and visceral, are related, and Phox2b serves as a developmental switch from the former to the latter. Expand
Enteric neuronal density contributes to the severity of intestinal inflammation.
TLDR
The severity of intestinal inflammation is associated with the density of the enteric innervation in mice, and abnormalities in development of theEnteric nervous system might contribute to the pathogenesis of inflammatory bowel disease. Expand
Hand2 is necessary for terminal differentiation of enteric neurons from crest-derived precursors but not for their migration into the gut or for formation of glia
TLDR
Enteric Hand2 expression is limited to crest-derived cells, whereas Hand1 expression is restricted to muscle and interstitial cells of Cajal, suggesting that enteric neuronal development occurs in stages and that Hand 2 expression is required for terminal differentiation but not for precursors to enter the neuronal lineage. Expand
Bone morphogenetic proteins regulate enteric gliogenesis by modulating ErbB3 signaling.
TLDR
The hypotheses that BMPs are required for enteric gliogenesis and act by promoting responsiveness of ENCDC to ErbB3 ligands such as GGF2 are supported. Expand
A Phox2b::FLPo transgenic mouse line suitable for intersectional genetics
TLDR
The P2b::FLPo line when partnered with a suitable Cre driver provides a tool for tracking and accessing genetically subsets of Phox2b‐expressing neuronal populations, which has not been possible by Cre‐mediated recombination alone. Expand
Phox2b expression in the taste centers of fish
TLDR
It is shown that Phox2b is expressed throughout the primary taste centers of two cyprinid fish, i.e., in their vagal, glossopharyngeal, and facial lobes, providing the first molecular evidence for their homology with the nucleus of the solitary tract of mammals and suggesting that a single ancestral Phox1b‐positive neuronal type evolved to give rise to both fish and mammalian structures. Expand
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