• Publications
  • Influence
Different embryo-fetal toxicity effects for three VLA-4 antagonists.
  • F. Crofts, M. Pino, R. Clark
  • Medicine, Biology
    Birth defects research. Part B, Developmental and…
  • 1 April 2004
TLDR
Dramatic differences in teratogenic potential were observed: IVL745 was not ter atogenic, HMR1031 caused slight embryo-fetal effects at maternally-toxic doses, and IVL984 was a potent teratogen at doses where direct maternal toxicity was limited to abortions in rabbits.
Critical period for a teratogenic VLA-4 antagonist: Developmental effects and comparison of embryo drug concentrations of teratogenic and non-teratogenic VLA-4 antagonists.
TLDR
The critical period for IVL984 in the rat, GD 10 to 11, corresponds to the expression of alpha-4 integrin on the chorion and VCAM-1 on the allantois and myocardium as well as chorioallantoic fusion and formation of the spiral septum.
PROCESS FOR THE PREPARATION OF ISOFLAVONES BACKGROUND OF THE INVENTION
Sekizaki, H., et al., Studies on Zoospore Attracting Activity. II. Synthesis of Isoflavones and Their Activity to Aphano myces euteiches Zoospore. Biol Pharm Bull. 16:698 (1993). Miles, C.O., et al.,