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- Publications
- Influence
Downregulation of the Mitochondrial Calcium Uniporter by Cancer-Related miR-25
Summary The recently discovered mitochondrial calcium uniporter (MCU) promotes Ca2+ accumulation into the mitochondrial matrix [1, 2]. We identified in silico miR-25 as a cancer-related MCU-targeting… Expand
miR-125b targets erythropoietin and its receptor and their expression correlates with metastatic potential and ERBB2/HER2 expression
- M. Ferracin, C. Bassi, +10 authors M. Negrini
- Medicine, Biology
- Molecular Cancer
- 28 October 2013
BackgroundThe microRNA 125b is a double-faced gene expression regulator described both as a tumor suppressor gene (in solid tumors) and an oncogene (in hematologic malignancies). In human breast… Expand
Liver tumorigenicity promoted by microRNA‐221 in a mouse transgenic model
- E. Callegari, B. K. Elamin, +16 authors M. Negrini
- Biology, Medicine
- Hepatology
- 1 September 2012
MicroRNA‐221 (miR‐221) is one of the most frequently and consistently up‐regulated microRNAs (miRNAs) in human cancer. It has been hypothesized that miR‐221 may act as a tumor promoter. To… Expand
Profiling of the Predicted Circular RNAs in Ductal In Situ and Invasive Breast Cancer: A Pilot Study
- M. Galasso, G. Costantino, +5 authors S. Volinia
- Biology, Medicine
- International journal of genomics
- 14 November 2016
The recent advantage obtained by next generation sequencing allows a depth investigation of a new “old” kind of noncoding transcript, the circular RNAs. Circular RNAs are nontranslated RNAs,… Expand
Loss of miR-204 expression is a key event in melanoma
- M. Galasso, C. Morrison, +15 authors S. Volinia
- Biology, Medicine
- Molecular Cancer
- 9 March 2018
Cutaneous melanoma (CM) is a malignancy with increasing occurrence. Its microRNA repertoire has been defined in a number studies, leading to candidates for biological and clinical relevance:… Expand
Heterogeneity in Circulating Tumor Cells: The Relevance of the Stem-Cell Subset
- Chiara Agnoletto, F. Corrà, +7 authors S. Volinia
- Biology, Medicine
- Cancers
- 1 April 2019
The release of circulating tumor cells (CTCs) into vasculature is an early event in the metastatic process. The analysis of CTCs in patients has recently received widespread attention because of its… Expand
Heterogeneous expression of EPCAM in human circulating tumour cells from patient-derived xenografts
- Chiara Agnoletto, Linda Minotti, +7 authors S. Volinia
- Biology, Medicine
- Biomarker Research
- 30 October 2018
BackgroundWe aim to characterize the heterogeneous circulating tumour cells (CTCs) in peripheral blood, independently of physical or immunological purification, by using patient-derived xenografts… Expand
Pluripotent stem cell miRNAs and metastasis in invasive breast cancer.
- S. Volinia, G. Nuovo, +30 authors R. Garzon
- Biology, Medicine
- Journal of the National Cancer Institute
- 1 December 2014
BACKGROUND
The purpose of this study is to determine whether microRNA for pluripotent stem cells are also expressed in breast cancer and are associated with metastasis and outcome.
METHODS
We… Expand
The Network of Non-coding RNAs in Cancer Drug Resistance
- F. Corrà, Chiara Agnoletto, Linda Minotti, Federica Baldassari, S. Volinia
- Biology, Medicine
- Front. Oncol.
- 29 August 2018
Non-coding RNAs (ncRNAs) have been implicated in most cellular functions. The disruption of their function through somatic mutations, genomic imprinting, transcriptional and post-transcriptional… Expand
Inhibiting the oncogenic mir-221 by microRNA sponge: toward microRNA-based therapeutics for hepatocellular carcinoma
- F. Moshiri, E. Callegari, +4 authors M. Negrini
- Medicine
- Gastroenterology and hepatology from bed to bench
- 12 January 2014
Aim We evaluated the capability of “microRNA sponges” in sequestering and inhibiting the over-expressed miR-221 in HCC cell lines. Background Advanced hepatocellular carcinoma (HCC) is a serious… Expand