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Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy
A previously unrecognized pathway for the activation of tumor antigen–specific T-cell immunity that involves secretion of the high-mobility-group box 1 (HMGB1) alarmin protein by dying tumor cells and the action of HMGB1 on Toll-like receptor 4 (TLR4) expressed by dendritic cells (DCs) is described.
Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): an observational study
General and abdominal adiposity and risk of death in Europe.
It is suggested that both general adiposity and abdominal adiposity are associated with the risk of death and support the use of waist circumference or waist-to-hip ratio in addition to BMI in assessing therisk of death.
European Prospective Investigation into Cancer and Nutrition (EPIC): study populations and data collection
The present paper provides a description of theEPIC study, with the aim of simplifying reference to it in future papers reporting substantive or methodological studies carried out in the EPIC cohort.
A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25
The results provide compelling evidence of a locus at 15q25 predisposing to lung cancer, and reinforce interest in nicotinic acetylcholine receptors as potential disease candidates and chemopreventative targets.
Modified Mediterranean diet and survival: EPIC-elderly prospective cohort study
The Mediterranean diet, modified so as to apply across Europe, was associated with increased survival among older people and no statistically significant evidence of heterogeneity was found.
Body size and risk of colon and rectal cancer in the European Prospective Investigation Into Cancer and Nutrition (EPIC).
Waist circumference and WHR, indicators of abdominal obesity, were strongly associated with colon cancer risk in men and women in this population and may vary depending on HRT use in postmenopausal women; however, these findings require confirmation in future studies.
Effects of long-term exposure to air pollution on natural-cause mortality: an analysis of 22 European cohorts within the multicentre ESCAPE project
Breast cancer risk in relation to different types of hormone replacement therapy in the E3N‐EPIC cohort
- A. Fournier, F. Berrino, E. Riboli, V. Avenel, F. Clavel-Chapelon
- Medicine, BiologyInternational journal of cancer
- 10 April 2005
The results suggest that, when combined with synthetic progestins, even short‐term use of estrogens may increase breast cancer risk, and Micronized progesterone may be preferred to synthetic progESTins in short-term HRT.
Postmenopausal breast cancer risk and dietary patterns in the E3N-EPIC prospective cohort study.
Adherence to a diet comprising mostly fruits, vegetables, fish, and olive/sunflower oil, along with avoidance of Western-type foods, may contribute to a substantial reduction in postmenopausal breast cancer risk.