Structural Basis for dsRNA Recognition, Filament Formation, and Antiviral Signal Activation by MDA5
- Bin Wu, A. Peisley, S. Hur
- 17 January 2013
Pkh-kinases control eisosome assembly and organization
- T. Walther, P. Aguilar, P. Walter
- Biology, Computer ScienceEMBO Journal
- 22 November 2007
Observations suggest that Pkh‐kinase signaling relayed to Pil1 may help regulate endocytic events to modulate the organization of the plasma membrane.
The Site-Specific Installation of Methyl-Lysine Analogs into Recombinant Histones
The epichaperome is an integrated chaperome network that facilitates tumour survival
- A. Rodina, Tai Wang, G. Chiosis
- 5 October 2016
It is found that under conditions of stress, such as malignant transformation fuelled by MYC, the chaperome becomes biochemically ‘rewired’ to form a network of stable, survival-facilitating, high-molecular-weight complexes.
An unfolded protein-induced conformational switch activates mammalian IRE1
- G. Karagöz, D. Acosta-Alvear, Hieu T Nguyen, Crystal P. Lee, F. Chu, P. Walter
- 29 September 2017
This work shows that similar to yeast, human IRE1α’s ER-lumenal domain (hIRE1α LD) binds peptides with a characteristic amino acid bias, and provides evidence for a unifying mechanism of IRE 1 activation that relies on unfolded protein binding-induced oligomerization.
Transcription factor binding to a DNA zip code controls interchromosomal clustering at the nuclear periphery.
- D. G. Brickner, Sara Ahmed, J. Brickner
- BiologyDevelopmental Cell
- 12 June 2012
Identification of a Novel Chromosomal Passenger Complex and Its Unique Localization during Cytokinesis in Trypanosoma brucei
- Ziyin Li, Ju Huck Lee, F. Chu, A. Burlingame, A. Günzl, Ching C. Wang
- BiologyPLoS ONE
- 11 June 2008
Four novel TbAUK1 associated proteins are identified by tandem affinity purification and mass spectrometry, indicating a most unusual CPC-initiated cytokinesis in a eukaryote.
Hdac6 regulates Tip60-p400 function in stem cells
- Poshen B. Chen, Jui-Hung Hung, T. Fazzio
- 3 December 2013
It is shown that the class II histone deacetylase Hdac6 co-purifies with Tip60-p400 complex from ESCs, and it is found that, like canonical subunits of Tip60 -p400, HdAC6 is necessary for robust ESC differentiation.
Acetylated H4K16 by MYST1 protects UROtsa cells from arsenic toxicity and is decreased following chronic arsenic exposure.
- W. J. Jo, X. Ren, Luoping Zhang
- BiologyToxicology and Applied Pharmacology
- 15 December 2009
Histone Acetylation and Chromatin Remodeling Are Required for UV-B–Dependent Transcriptional Activation of Regulated Genes in Maize[W]
Chromatin remodeling is shown to be a key process in acclimation to UV-B, and lines deficient in this process are more sensitive toUV-B.