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Planarian homologs of netrin and netrin receptor are required for proper regeneration of the central nervous system and the maintenance of nervous system architecture
RNAi analyses indicate that Smed-netR (netrin receptor) and SMed-netrin2 are required for proper CNS regeneration and that S med-netsR may mediate the response to Smed -netrin 2. Expand
Regeneration and maintenance of the planarian midline is regulated by a slit orthologue.
It is suggested that Smed-slit acts not only as a repulsive cue required for proper midline formation during regeneration but that it may also act to regulate the behavior of neural precursors at the midline in intact planarians. Expand
FGFR-related gene nou-darake restricts brain tissues to the head region of planarians
The identification and characterization of nou-darake (ndk), a gene encoding a fibroblast growth factor receptor (FGFR)-like molecule specifically expressed in the head region of the planarian Dugesia japonica, and the data suggest that ndk may modulate FGF signalling in stem cells to restrict brain tissues to theHead region of planarians. Expand
The BMP pathway is essential for re-specification and maintenance of the dorsoventral axis in regenerating and intact planarians.
The results suggest that the BMP signaling pathway is conserved in planarians and that it plays a key role in the regeneration and maintenance of the dorsoventral axis. Expand
Regenerating the central nervous system: how easy for planarians!
  • F. Cebrià
  • Biology, Medicine
  • Development Genes and Evolution
  • 13 November 2007
Current knowledge on the planarian nervous system and the genes involved in its regeneration are discussed, and some of the important questions that remain to be answered are discussed. Expand
The expression of neural-specific genes reveals the structural and molecular complexity of the planarian central nervous system
New molecular domains within the brain of intact planarians are described by the expression of 16 planarian neural-specific genes, including the putative homologues of protein tyrosine phosphatase receptor, synaptotagmin VII, slit, G protein and glutamate and acetylcholine receptors, by in situ hybridization in both whole-mount and transverse sections. Expand
Dissecting planarian central nervous system regeneration by the expression of neural‐specific genes
The results from this study show that the comparison of the expression patterns of different neural genes supports the view that at day one of regeneration, the new brain appears within the blastema, whereas the pre‐existing ventral nerve cords remain in the old tissues. Expand
The planarian flatworm: an in vivo model for stem cell biology and nervous system regeneration
Why planarians are an exciting tool in the study of regeneration and its underlying stem cell biology in vivo is highlighted, and the potential promises and current limitations of this model organism for stem cell research and regenerative medicine are discussed. Expand
Origin and evolutionary process of the CNS elucidated by comparative genomics analysis of planarian ESTs
Comparisons of planarian EST clones with all ORFs of the complete genome sequences of the human, fruit fly, and nematode showed that >95% of these 116 nervous system-related genes were commonly shared among these organisms, thus providing evidence at the molecular level for the existence of a common ancestral CNS. Expand
Noggin and Noggin-Like Genes Control Dorsoventral Axis Regeneration in Planarians
It is shown that a BMP/ADMP organizer governs DV axis reestablishment during planarian regeneration, highlighting a greater-than-thought conservation of the mechanisms that establish this axis in protostomes and deuterostomes. Expand