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Runs of homozygosity: windows into population history and trait architecture
Long runs of homozygosity (ROH) arise when identical haplotypes are inherited from each parent and thus a long tract of genotypes is homozygous. Cousin marriage or inbreeding gives rise to suchExpand
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The Role of Inbreeding in the Extinction of a European Royal Dynasty
The kings of the Spanish Habsburg dynasty (1516–1700) frequently married close relatives in such a way that uncle-niece, first cousins and other consanguineous unions were prevalent in that dynasty.Expand
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Assessing runs of Homozygosity: a comparison of SNP Array and whole genome sequence low coverage data
BackgroundRuns of Homozygosity (ROH) are genomic regions where identical haplotypes are inherited from each parent. Since their first detection due to technological advances in the late 1990s, ROHsExpand
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Runs of Homozygosity
(ROH). Contiguous regions of the genome where an individual is homozygous across all sites. T his arises if the haplotypes transmitted from the mother and father are identical, having in turn beenExpand
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Was the Darwin/Wedgwood Dynasty Adversely Affected by Consanguinity?
Charles Darwin, who was married to his first cousin, Emma Wedgwood, was one of the first experimentalists to demonstrate the adverse effects of inbreeding and to question the consequences ofExpand
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Inbreeding and Genetic Disorder
Inbreeding is usually defined as the mating between relatives and the progeny that result of a consanguineous mating between two related individuals is said to be inbred (CavalliSforza & Bodmer,Expand
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Royal dynasties as human inbreeding laboratories: the Habsburgs
The European royal dynasties of the Early Modern Age provide a useful framework for human inbreeding research. In this article, consanguineous marriage, inbreeding depression and the purging ofExpand
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Darwin was right: inbreeding depression on male fertility in the Darwin family
Charles Darwin, who was married to his first cousin Emma Wedgwood, was the first experimentalist to demonstrate the adverse effects of inbreeding. He documented the deleterious consequences ofExpand
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Royal Inbreeding and the Extinction of Lineages of the Habsburg Dynasty
Objective: The impact of inbreeding in the two branches of the Habsburg dynasty, the Spanish and the Austrian Habsburgs, is investigated to explain why the Spanish lineage was extinguished at the endExpand
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Runs of homozygosity in sub-Saharan African populations provide insights into complex demographic histories
The study of runs of homozygosity (ROH) can shed light on population demographic history and cultural practices. We present a fine-scale ROH analysis of 1679 individuals from 28 sub-Saharan AfricanExpand
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