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Hereditary diffuse gastric cancer: updated consensus guidelines for clinical management and directions for future research
25–30% of families fulfilling the criteria for hereditary diffuse gastric cancer have germline mutations of the CDH1 (E-cadherin) gene. In light of new data and advancement of technologies, aExpand
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Geographic distribution of vacA allelic types of Helicobacter pylori.
BACKGROUND & AIMS Distinct allelic types of Helicobacter pylori vacA have been defined. The geographic distribution of vacA alleles and cagA was assessed in this study. METHODS A total of 735Expand
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A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function
microRNAs (miRNAs) are small noncoding RNAs that regulate gene expression by targeting messenger RNA (mRNA) transcripts. Recently, a miRNA expression profile of human tumors has been characterized byExpand
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Familial gastric cancer: overview and guidelines for management*
Families with autosomal dominant inherited predisposition to gastric cancer have been described. More recently, germlineE-cadherin/CDH1mutations have been identified in hereditary diffuse gastricExpand
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Helicobacter pylori and interleukin 1 genotyping: an opportunity to identify high-risk individuals for gastric carcinoma.
BACKGROUND Both Helicobacter pylori genotype and host genetic polymorphisms play a role in determining the clinical consequences of H. pylori infection. We investigated whether there are anyExpand
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Intestinal metaplasia of human stomach displays distinct patterns of mucin (MUC1, MUC2, MUC5AC, and MUC6) expression.
Intestinal metaplasia is a well-established premalignant condition of the stomach that is characterized by mucin carbohydrate modifications defined by histochemical methods. The purpose of theExpand
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Typing of Helicobacter pylori vacA Gene and Detection of cagA Gene by PCR and Reverse Hybridization
ABSTRACT The present report describes an analysis of two virulence genes ofHelicobacter pylori. Parts of the cagA gene, as well as parts from the signal (s) and middle (m) regions of the mosaicvacAExpand
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The prevalence of PIK3CA mutations in gastric and colon cancer.
A wide variety of tumours show PIK3CA mutations leading to increased phosphatidylinositol-3 kinase (PI3K) activity. We have determined the frequency of PIK3CA mutations in exons 9 and 20 that hasExpand
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Interleukin 1B and interleukin 1RN polymorphisms are associated with increased risk of gastric carcinoma.
BACKGROUND & AIMS Interleukin (IL)-1 gene cluster proinflammatory polymorphisms have been associated with development of gastric atrophy and with increased risk of gastric carcinoma. We aimed toExpand
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Familial gastric cancer: genetic susceptibility, pathology, and implications for management.
Familial gastric cancer comprises at least three major syndromes: hereditary diffuse gastric cancer, gastric adenocarcinoma and proximal polyposis of the stomach, and familial intestinal gastricExpand
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