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Flavonoids: old and new aspects of a class of natural therapeutic drugs.
This review summarizes available data on these beneficial effects of flavonoids and suggests that the compounds may possess significant antihepatotoxic, antiallergic, anti-inflammatory, antiosteoporotic and even antitumor activities.
Propolis, an old remedy used in modern medicine.
Propolis is one of the few natural remedies that has maintained its popularity over a long period of time and has anti-inflammatory and immunomodulatory activities and has been shown to lower blood pressure and cholesterol levels.
Cannabinoid CB1‐receptor mediated regulation of gastrointestinal motility in mice in a model of intestinal inflammation
- A. Izzo, F. Fezza, +7 authors F. Capasso
- Biology, MedicineBritish journal of pharmacology
- 1 October 2001
It is concluded that inflammation of the gut increases the potency of cannabinoid agonists possibly by ‘up‐regulating’ CB1 receptor expression; in addition, endocannabinoids, whose turnover is increased in inflamed gut, might tonically inhibit intestinal motility.
Antibacterial activity of Cuminum cyminum L. and Carum carvi L. essential oils.
- N. Iacobellis, P. Lo Cantore, F. Capasso, F. Senatore
- Chemistry, MedicineJournal of agricultural and food chemistry
- 12 January 2005
Antibacterial activity was particularly high against the genera Clavibacter, Curtobacterium, Rhodococcus, Erwinia, Xanthomonas, Ralstonia, and Agrobacteria, which are responsible for plant or cultivated mushroom diseases worldwide.
Endocannabinoids as physiological regulators of colonic propulsion in mice.
Endocannabinoids acting on myenteric CB1 receptors tonically inhibit colonic propulsion in mice, and high amounts of 2-arachidonylglycerol and particularly anandamide were found in the colon, together with a high activity of an andamide amidohydrolase.
Milk thistle in liver diseases: past, present, future
- L. Abenavoli, R. Capasso, N. Milić, F. Capasso
- Biology, MedicinePhytotherapy research : PTR
- 1 October 2010
Silymarin has been used to treat alcoholic liver disease, acute and chronic viral hepatitis and toxin‐induced liver diseases, and may act as a toxin blockade agent by inhibiting binding of toxins to the hepatocyte cell membrane receptors.
Nitric Oxide as a Modulator of Intestinal Water and Electrolyte Transport
Clinical studies have shown that nitric oxide is elevated in several inflammatorybowel diseases and other secretory conditions includingulcerative colitis, Crohn's disease, toxic megacolon, diverticulitis, infectious gastroenteritis, andinfantile methemoglobinemia, but the determination of nitric oxidesynthase in secretory diarrhea per se does not give conclusive information on theNitric oxide contribution to clinical secretorydiarrhea.
Phytochemical compounds involved in the anti-inflammatory effect of propolis extract.
Results suggest that the anti-inflammatory activity of propolis is due to CAPE, and EPE without CAPE and galangin did not exhibit anti- inflammation effects in acute and chronic inflammation.
Effects of quercetin on the gastrointestinal tract in rats and mice
It is suggested that α2‐adrenergic receptors mediate the effect of quercetin on intestinal motility and secretion.
Cannabidiol, a safe and non-psychotropic ingredient of the marijuana plant Cannabis sativa, is protective in a murine model of colitis
Cannabidiol, a likely safe compound, prevents experimental colitis in mice and reduces colon injury and endocannabinoid changes associated with 2,4,6-dinitrobenzene sulfonic acid administration.