• Publications
  • Influence
p53 mRNA controls p53 activity by managing Mdm2 functions
TLDR
It is shown that the p53 mRNA region encoding the Mdm2-binding site interacts directly with the RING domain of MDM2, which impairs the E3 ligase activity of Mdn2 and promotes p53 RNA translation and indicates that Mdm 2-mediated control of p53 synthesis and degradation has evolved in the p 53 mRNA sequence and its encoded amino acids. Expand
The immune response to p53 in breast cancer patients is directed against immunodominant epitopes unrelated to the mutational hot spot.
TLDR
It is found that the B-cell response to p53 protein is induced by two immunodominant regions located at the carboxy and amino termini of the protein, outside the central mutational hot spot region. Expand
Proprotein convertases: lessons from knockouts
TLDR
The major in vivo defects that result from the disruption of the expression of the PC genes are summarized, including abnormal embryonic development, hormonal disorder, infertility, and/or modified lipid/sterol metabolism. Expand
Immortalization of human adult normal prostatic epithelial cells by liposomes containing large T-SV40 gene.
TLDR
For the first time to the authors' knowledge, the immortalization of normal adult prostatic epithelial cells in culture by transfection of a plasmid containing SV40 genome with a defective replication origin encapsulated into liposomes is reported. Expand
SIAH-1 interacts with α-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis
TLDR
The results suggest that SIAH-1 but not its N-terminal deletion mutant, affects the mitosis by an enhanced reduction of kinesin levels, implying, for the first time, SIAh-1 in regulating the degradation of proteins directly implicated in the mitotic process. Expand
The antiapoptotic protein AAC‐11 interacts with and regulates Acinus‐mediated DNA fragmentation
TLDR
It is reported here that AAC‐11, a survival protein whose expression prevents apoptosis that occurs on deprivation of growth factors, physiologically binds to Acinus and prevents Acinus‐mediated DNA fragmentation, and targeting AAC‐ 11 might be a potent strategy for cancer treatment by sensitization of tumour cells to chemotherapeutic drugs. Expand
Lung abnormalities after dasatinib treatment for chronic myeloid leukemia: a case series.
TLDR
Lung physicians should be aware that lung manifestations, presumably related to an immune-mediated mechanism rather than fluid retention, may occur with dasatinib treatment, and be aware of any changes in parenchyma changes. Expand
In vivo mechanisms of resistance to cytarabine in acute myeloid leukaemia
TLDR
expression of DNA POL, 5NT and hENT1 at diagnosis may be resistance mechanisms to ara‐C in AML patients, suggesting chemoresistance in acute myeloid leukaemia patients. Expand
Regulation of extracellular matrix metalloproteinase inducer and matrix metalloproteinase expression by amphiregulin in transformed human breast epithelial cells.
TLDR
AR and epidermal growth factor regulate EMMPRIN and its MMP-mediated expression, identifying EGFR signaling as critical to this regulation. Expand
Differential expression of extracellular matrix metalloproteinase inducer (CD147) in normal and ulcerated corneas: role in epithelio-stromal interactions and matrix metalloproteinase induction.
TLDR
A role for EMMPRIN in wound healing is demonstrated and sustained local up-regulation of EMM PRIN and MMPs in chronic situations in which healing is delayed may lead to excessive matrix degradation and corneal melts. Expand
...
1
2
3
4
5
...