RU486 (mifepristone): mechanisms of action and clinical uses.
- F. Cadepond, A. Ulmann, E. Baulieu
- Medicine, BiologyAnnual Review of Medicine
Clinically, the RU486-plus-prostaglandin method is close to being as convenient and safe as any medical method of abortion may be and the early use of RU486 as a contragestive as soon as a woman fears a pregnancy she does not want will help to defuse the abortion issue.
Etifoxine improves peripheral nerve regeneration and functional recovery
- C. Girard, Song Liu, G. Schweizer-Groyer
- Biology, MedicineProceedings of the National Academy of Sciences
- 23 December 2008
This work demonstrates that etifoxine, a clinically approved drug already used for the treatment of anxiety disorders, is remarkably efficient in promoting acceleration of peripheral nerve regeneration and functional recovery.
3alpha,5alpha-Tetrahydroprogesterone (allopregnanolone) and gamma-aminobutyric acid: autocrine/paracrine interactions in the control of neonatal PSA-NCAM+ progenitor proliferation.
- N. Gago, M. El‐Etr, M. Schumacher
- BiologyJournal of Neuroscience Research
The results reveal complex autocrine/paracrine loops in the control of ePSA-NCAM+ progenitor proliferation, involving both neurosteroid and GABA signaling, and suggest a novel key role for 3alpha,5alpha-THP in the development of the nervous system.
Phenylbutyrate up-regulates the adrenoleukodystrophy-related gene as a nonclassical peroxisome proliferator
- C. Gondcaille, M. Depreter, M. Bugaut
- Biology, MedicineJournal of Cell Biology
- 11 April 2005
4-Phenylbutyrate is a nonclassical peroxisome proliferator inducing pleiotropic effects, including effects at theperoxisomal level mainly through HDAC inhibition.
Hormonal regulation of the nuclear localization signals of the human glucocorticosteroid receptor.
- F. Cadepond, J. Gasc, E. Baulieu
- BiologyExperimental Cell Research
- 1 July 1992
3α,5α‐tetrahydroprogesterone (allopregnanolone) and γ‐aminobutyric acid: Autocrine/paracrine interactions in the control of neonatal PSA‐NCAM+ progenitor proliferation
- N. Gago, M. El‐Etr, M. Schumacher
- 15 December 2004
The results reveal complex autocrine/paracrine loops in the control of ePSA‐NCAM+ progenitor proliferation, involving both neurosteroid and GABA signaling, and suggest a novel key role for 3α,5α‐THP in the development of the nervous system.
Thyroid hormone induction of the adrenoleukodystrophy-related gene (ABCD2).
- S. Fourcade, S. Savary, M. Bugaut
- Biology, MedicineMolecular Pharmacology
- 1 June 2003
It is reported for the first time that induction of the ABCD2 redundant gene is feasible in myelin-producing cells (differentiated CG4 oligodendrocytes) and was specific for this cell type because it did not occur in astrocytic cells.
Glucocorticosteroid receptor dimerization investigated by analysis of receptor binding to glucocorticosteroid responsive elements using a monomer-dimer equilibrium model.
- I. Segard-Maurel, K. Rajkowski, N. Jibard, G. Schweizer-Groyer, E. Baulieu, F. Cadepond
- 6 February 1996
Dimmerization of the DBD was not increased by the presence of only one of the GR terminal domains, but an increase in dimerization efficiency was observed when both domains were present, suggesting a structural synergy between the N- and C-terminal domains in GR homodimerization.
The molecular chaperone Hsp90 can negatively regulate the activity of a glucocorticosteroid-dependent promoter.
- K. Kang, X. Meng, M. Catelli
- BiologyProceedings of the National Academy of Sciences…
- 16 February 1999
It is proposed that an increased Hsp90/GR ratio influences the responsiveness to ligand at a step that is after receptor activation, and this increased ratio may be of pathophysiological relevance in the different circumstances that lead to an elevated level of nuclear HSp90.
Receptor‐Associated Nuclear Proteins and Steroid/ Antisteroid Action
- E. Baulieu, N. Binart, M. Sabbah
- BiologyAnnals of the New York Academy of Sciences
- 1 June 1990
Very early steps in steroid hormone (and antihormone) action, immediately after binding of hormone to the receptor (R) are deals with, and a working hypothesis is that hsp 90 is responsible for the lack of DNA binding by the 8S-Rs, and released when.