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Enterohepatic Circulation
Enterohepatic recycling occurs by biliary excretion and intestinal reabsorption of a solute, sometimes with hepatic conjugation and intestinal deconjugation. Cycling is often associated with multipleExpand
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Antibiotic‐Heparin Lock: In Vitro Antibiotic Stability Combined with Heparin in a Central Venous Catheter
Long‐term hemodialysis frequently requires vascular access through central venous catheters (CVCs). Infection related to these catheters is a significant complication. The use of anExpand
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The Role of Extracellular Binding Proteins in the Cellular Uptake of Drugs: Impact on Quantitative In Vitro-to-In Vivo Extrapolations of Toxicity and Efficacy in Physiologically Based
A critical component in the development of physiologically based pharmacokinetic-pharmacodynamic (PBPK/PD) models for estimating target organ dosimetry in pharmacology and toxicology studies is theExpand
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Molecular mechanism of recombinant liver fatty acid binding protein's antioxidant activity
Hepatocytes expressing liver fatty acid binding protein (L-FABP) are known to be more resistant to oxidative stress than those devoid of this protein. The mechanism for the observed antioxidantExpand
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Development of a nitric oxide-releasing analogue of the muscle relaxant guaifenesin for skeletal muscle satellite cell myogenesis.
Nitric oxide (NO) mediates activation of satellite precursor cells to enter the cell cycle. This provides new precursor cells for skeletal muscle growth and muscle repair from injury or disease.Expand
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Intrahepatic blood flow distribution in the perfused rat liver: effect of hepatic artery perfusion.
Variations in blood flow to different sinusoids within the liver can prevent uniform uptake of solutes from plasma and contribute to cellular ischemia in low-flow states. However, the degree ofExpand
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Saikosaponin A of Bupleurum chinense (Chaihu) elevates bone morphogenetic protein 4 (BMP-4) during hepatic stellate cell activation.
BACKGROUND Saikosaponin a (SSa) is a compound extracted from a Chinese herb which has been widely used in treating liver diseases such as liver fibrosis. However, the mechanism of SSa in treatment ofExpand
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Chemical Marker Profile and Biological Effects of Natural Products Containing Echinacea
Natural health products containing Echinacea have been used by many patient populations and although there are reports of adverse effects with products containing Echinacea, few clearly characterizedExpand
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Antioxidative function of L‐FABP in L‐FABP stably transfected Chang liver cells
Liver fatty acid binding protein (L‐FABP) contains amino acids that are known to possess antioxidant function. In this study, we tested the hypothesis that L‐FABP may serve as an effective endogenousExpand
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Palmitate uptake by cultured hepatocytes: albumin binding and stagnant layer phenomena.
We compared uptake of palmitate by hepatocyte monolayers with uptake by polyethylene membranes under conditions of identical binding and stirring. Hepatocytes and polyethylene display similarExpand
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